96389-68-3
96389-68-3 structure
- Name: Crisnatol
- Chemical Name: 2-(chrysen-6-ylmethylamino)-2-methylpropane-1,3-diol
- CAS Number: 96389-68-3
- Molecular Formula: C23H23NO2
- Molecular Weight: 345.43400
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2017-03-09 06:42:35
- Modify Date: 2024-03-09 20:26:07
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Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against MCF-7 human breast cancer cells, breast cancer cell line (MDA-MB-231), but not normal human skin fibroblasts[1][2][3].
| Name | 2-(chrysen-6-ylmethylamino)-2-methylpropane-1,3-diol |
|---|---|
| Synonyms |
2-((6-chrysenylmethyl)amino)-2-methyl-1,3-propanediol
Crisnatol [INN] UNII-2J71UR51UE 1,3-Propanediol,2-((6-chrysenylmethyl)amino)-2-methyl Crisnatolum [Latin] CRISNATOL Crisnatolum |
| Description | Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against MCF-7 human breast cancer cells, breast cancer cell line (MDA-MB-231), but not normal human skin fibroblasts[1][2][3]. |
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| Related Catalog | |
| In Vitro | Crisnatol (1.3 μg/mL; 24, 48, 72 h) inhibits the replication of HepG2 cells, decreases cell viability by only 35%[2]. Crisnatol (0.05 μg/mL, 0.5 μg/mL; 1 μg/mL; 24 h; 37 ℃) drug metabolites chromatographic properties in both Hep G2 cells and human liver microsomes is similar to metabolites observed in extracts of feces from rats[2]. Cell Viability Assay[2] Cell Line: HepG2 cells Concentration: 1.3 μg/mL Incubation Time: 24 hours, 48 hours, 72 hours, and 126 hours Result: Inhibited cell viability at 48 hr. |
| In Vivo | Crisnatol (25 mg/kg; p.o.; single dose) shows oral activity and shows stable metabolite profile extract of rat feces by autoradiography[2]. |
| Density | 1.242g/cm3 |
|---|---|
| Boiling Point | 620.9ºC at 760mmHg |
| Molecular Formula | C23H23NO2 |
| Molecular Weight | 345.43400 |
| Flash Point | 194.5ºC |
| Exact Mass | 345.17300 |
| PSA | 52.49000 |
| LogP | 4.37000 |
| Index of Refraction | 1.72 |
| HS Code | 2922199090 |
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| HS Code | 2922199090 |
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| Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |