72593-77-2

72593-77-2 structure

Name: Methyl-PEG3-bromide
Chemical Name: Diethylene Glycol 2-Bromoethyl Methyl Ether
CAS Number: 72593-77-2
Molecular Formula: C₇H₁₅BrO₃
Molecular Weight: 227.09600
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-23 12:32:04
Modify Date: 2024-01-01 22:23:35
Methyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Diethylene Glycol 2-Bromoethyl Methyl Ether
Synonyms	1-[2-(2-bromoethoxy)ethoxy]-2-methoxyethane

Description	Methyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
RIDADR	NONH for all modes of transport

112-35-6

~86%

72593-77-2

Literature: Karimi, Babak; Mansouri, Fariborz; Vali, Hojatollah Green Chemistry, 2014 , vol. 16, # 5 p. 2587 - 2596

112-49-2

~67%

72593-77-2

Literature: Wakim, Salem; Bouchard, Jimmy; Blouin, Nicolas; Michaud, Alexandre; Leclerc, Mario Organic Letters, 2004 , vol. 6, # 19 p. 3413 - 3416

62921-74-8

~93%

72593-77-2

Literature: Schou, Ole; Larsen, Per Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1981 , vol. 35, # 5 p. 337 - 340