934995-87-6

934995-87-6 structure

Name: MK-0952
Chemical Name: (1R,2R)-2-{3'-[3-(Cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridin-1( 4H)-yl]-3-fluoro-4-biphenylyl}cyclopropanecarboxylic acid
CAS Number: 934995-87-6
Molecular Formula: C₂₈H₂₂FN₃O₄
Molecular Weight: 483.49000
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2017-02-18 17:05:22
Modify Date: 2024-01-08 18:55:12
MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study[1][2].

Name	(1R,2R)-2-{3'-[3-(Cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridin-1( 4H)-yl]-3-fluoro-4-biphenylyl}cyclopropanecarboxylic acid

Description	MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease
Target	PDE4:0.53 nM (IC50)
In Vivo	MK-0952 (10 mg/kg) induces malaise in the rat[1].
References	[1]. Michel Gallant, et al. Discovery of MK-0952, a Selective PDE4 Inhibitor for the Treatment of Long-Term Memory Loss and Mild Cognitive Impairment. Epub 2010 Sep 21. [2]. Tingting Pan, et al. Dual Functional Cholinesterase and PDE4D Inhibitors for the Treatment of Alzheimer's Disease: Design, Synthesis and Evaluation of tacrine-pyrazolo[3,4-b]pyridine Hybrids. Behav Brain Res. 2016 Apr 15;303:26-33.