56005-10-8

56005-10-8 structure

Name: 2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE
Chemical Name: 5-O-methyl embelin
CAS Number: 56005-10-8
Molecular Formula: C₁₈H₂₈O₄
Molecular Weight: 308.41300
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2018-12-01 00:32:37
Modify Date: 2024-01-03 17:21:20
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, low-density lipoprotein receptor (IDOL), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].

Name	5-O-methyl embelin
Synonyms	5-O-Methylembelin 2-hydroxy-5-methoxy-3-undecylcyclohexa-2,5-diene-1,4-dione

Description	5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, low-density lipoprotein receptor (IDOL), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cardiovascular Disease
In Vitro	5-O-Methylembelin（compound 3；20 μM；24 小时）显着下调 PCSK9（IC50 值为 4.9 μM）、IDOL 和 SREBP2 mRNA 表达[1]。 RT-PCR[1] Cell Line: HepG2 cells Concentration: 20 μM Incubation Time: 24 h Result: Inhibited PCSK9, IDOL, and SREBP2 mRNA expression.
References	[1]. Pisey Pel, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega. 2022 Dec 8;7(50):47296-47305.

HS Code	2914690090

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%