15763-11-8

15763-11-8 structure

Name: 2-Hydrazinyl-adenosine
Chemical Name: 2-Hydrazino Adenosine
CAS Number: 15763-11-8
Molecular Formula: C₁₀H₁₅N₇O₄
Molecular Weight: 297.27
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2017-03-02 12:21:49
Modify Date: 2024-01-19 15:08:40
2-Hydrazinyl-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	2-Hydrazino Adenosine
Synonyms	(2R,3R,4S,5R)-2-(6-amino-2-hydrazinylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Description	2-Hydrazinyl-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	2.29±0.1 g/cm3(Predicted)
Boiling Point	583.1±60.0 °C(Predicted)
Melting Point	208-210ºC
Molecular Formula	C₁₀H₁₅N₇O₄
Molecular Weight	297.27
Exact Mass	297.11900
PSA	177.59000
Index of Refraction	2.002
Storage condition	2-8°C

Hazard Codes	Xn

146-78-1

~94%

15763-11-8

Literature: RELIABLE BIOPHARMACEUTICAL CORPORATION; WOOLDRIDGE, Luzviminda, T.; MA, Chun; NADJI, Sourena Patent: WO2012/149196 A1, 2012 ; Location in patent: Page/Page column 17 ;

146-77-0

~82%

15763-11-8

Literature: CV THERAPEUTICS, INC. Patent: WO2008/143667 A1, 2008 ; Location in patent: Page/Page column 20-21 ; WO 2008/143667 A1

35109-88-7

~83%

15763-11-8

Literature: Van Tilburg, Erica W.; Von Frijtag Drabbe Kuenzel, Jacobien; De Groote, Miriam; IJzerman, Ad P. Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 420 - 429

79999-39-6

~88%

15763-11-8

Literature: Niiya; Olsson; Thompson; Silvia; Ueeda Journal of Medicinal Chemistry, 1992 , vol. 35, # 24 p. 4557 - 4561

15465-92-6

15763-11-8

Literature: Schaeffer; Thomas Journal of the American Chemical Society, 1958 , vol. 80, p. 3738,3741

118-00-3

15763-11-8

Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447

6979-94-8

15763-11-8

Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447

16321-99-6

15763-11-8

Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447

3056-18-6

15763-11-8

Literature: El-Tayeb, Ali; Gollos, Sabrina Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447

Precursor 9
146-78-1 146-77-0 35109-88-7 79999-39-6
15465-92-6 118-00-3 6979-94-8 16321-99-6
3056-18-6
DownStream 2
59587-07-4 58-61-7

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940364-43-2	2680712-38-1
2228790-39-2	134104-43-1
131615-57-1	2227977-03-7
6906-52-1	930439-75-1