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16321-99-6

16321-99-6 structure
16321-99-6 structure
  • Name: 2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside
  • Chemical Name: (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
  • CAS Number: 16321-99-6
  • Molecular Formula: C16H18ClN5O7
  • Molecular Weight: 427.80
  • Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
  • Create Date: 2018-11-28 00:10:30
  • Modify Date: 2024-01-14 06:46:10
  • 2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Name (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
Synonyms 2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine Riboside
2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine
[(2R,3S,4S,5R)-3,4-diacetyloxy-5-(2-amino-6-chloropurin-9-yl)oxolan-2-yl]methyl acetate
Description 2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Density 1.7g/cm3
Boiling Point 637ºC at 760mmHg
Melting Point 146.0 to 150.0 °C
Molecular Formula C16H18ClN5O7
Molecular Weight 427.80
Flash Point 339ºC
Exact Mass 427.08900
PSA 157.75000
LogP 0.96700
Vapour Pressure 4E-16mmHg at 25°C
Index of Refraction 1.69
2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine Riboside Revision number: 5
SAFETY DATA SHEET
Section1. IDENTIFICATION
2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine Riboside
Product name:


5
Revision number:
Section2. HAZARDS IDENTIFICATION
GHS classification
Not classified
PHYSICAL HAZARDS
Not classified
HEALTH HAZARDS
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements, including precautionary statements
None
Pictograms or hazard symbols
No signal word
Signal word
None
Hazard statements
None
Precautionary statements:
Section3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance
Substance/mixture:
2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine Riboside
Components:
>97.0%(LC)(T)
Percent:
16321-99-6
CAS Number:
2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine
Synonyms:
C16H18ClN5O7
Chemical Formula:
Section4. FIRST AID MEASURES
Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Inhalation:
Get medical advice/attention if you feel unwell.
Remove/Take off immediately all contaminated clothing. Rinse skin with
Skin contact:
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Rinse cautiously with water for several minutes. Remove contact lenses, if present
Eye contact:
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Get medical advice/attention if you feel unwell. Rinse mouth.
Ingestion:
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.
Section5. FIRE-FIGHTING MEASURES
Dry chemical, foam, water spray, carbon dioxide.
Suitable extinguishing
media:
Take care as it may decompose upon combustion or in high temperatures to
Specific hazards arising
generate poisonous fume.
from the chemical:
2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine
Riboside
Section5. FIRE-FIGHTING MEASURES
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
When extinguishing fire, be sure to wear personal protective equipment.
Special protective
equipment for firefighters:
Section6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.
Section7. HANDLING AND STORAGE
Precautions for safe handling
Handling is performed in a well ventilated place. Wear suitable protective equipment.
Technical measures:
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Keep container tightly closed. Store in a cool and dark place.
Storage conditions:
Store away from incompatible materials such as oxidizing agents.
Comply with laws.
Packaging material:
Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Install a closed system or local exhaust as possible so that workers should not be
Engineering controls:
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Protective gloves.
Hand protection:
Safety glasses. A face-shield, if the situation requires.
Eye protection:
Skin and body protection: Protective clothing. Protective boots, if the situation requires.
Section9. PHYSICAL AND CHEMICAL PROPERTIES
Solid
Physical state (20°C):
Crystal- Powder
Form:
Slightly pale yellow - Yellow
Colour:
No data available
Odour:
pH: No data available
Melting point/freezing point:148°C
No data available
Boiling point/range:
No data available
Flash point:
Flammability or explosive
limits:
No data available
Lower:
No data available
Upper:
No data available
Relative density:
Solubility(ies):
No data available
[Water]
No data available
[Other solvents]
2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine
Riboside
Section10. STABILITY AND REACTIVITY
Stable under proper conditions.
Chemical stability:
No special reactivity has been reported.
Possibility of hazardous
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Hydrogen chloride
products:
Section11. TOXICOLOGICAL INFORMATION
No data available
Acute Toxicity:
No data available
Skin corrosion/irritation:
No data available
Serious eye
damage/irritation:
No data available
Germ cell mutagenicity:
Carcinogenicity:
No data available
IARC =
No data available
NTP =
No data available
Reproductive toxicity:
Section12. ECOLOGICAL INFORMATION
Ecotoxicity:
No data available
Fish:
No data available
Crustacea:
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobility in soil
No data available
Log Pow:
No data available
Soil adsorption (Koc):
No data available
Henry's Law
constant(PaM3/mol):
Section13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.
Section14. TRANSPORT INFORMATION
Does not correspond to the classification standard of the United Nations
Hazards Class:
Not listed
UN-No:
Section15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.
2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine
Riboside

SECTION 16 - ADDITIONAL INFORMATION
N/A
6979-94-8 structure

6979-94-8

~96%

16321-99-6 structure

16321-99-6

Literature: Kamaike; Kinoshita; Niwa; Hirose; Suzuki; Ishido Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 1-2 p. 59 - 75
2004-07-1 structure

2004-07-1

108-24-7 structure

108-24-7

~90%

16321-99-6 structure

16321-99-6

Literature: Ohno, Michihiro; Gao, Zhan-Guo; Van Rompaey, Philippe; Tchilibon, Susanna; Kim, Soo-Kyung; Harris, Brian A.; Gross, Ariel S.; Duong, Heng T.; Van Calenbergh, Serge; Jacobson, Kenneth A. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2995 - 3007
118-00-3 structure

118-00-3

~%

16321-99-6 structure

16321-99-6

Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 5-7 p. 717 - 720
28708-32-9 structure

28708-32-9

10310-21-1 structure

10310-21-1

~%

16321-99-6 structure

16321-99-6

Literature: Chinese Journal of Chemistry, , vol. 31, # 9 p. 1207 - 1218
335060-20-3 structure

335060-20-3

~%

16321-99-6 structure

16321-99-6

Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 1-2 p. 59 - 75
335060-31-6 structure

335060-31-6

~%

16321-99-6 structure

16321-99-6

Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 1-2 p. 59 - 75
335060-33-8 structure

335060-33-8

~%

16321-99-6 structure

16321-99-6

Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 1-2 p. 59 - 75
108-24-7 structure

108-24-7

118-00-3 structure

118-00-3

~%

16321-99-6 structure

16321-99-6

Literature: Synthesis, , # 6 p. 450 - 453

Chemsrc provides CAS#:16321-99-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 16321-99-6 | Chemsrc address: https://www.chemsrc.com/en/baike/2522.html

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