96895-25-9

96895-25-9 structure

Name: Nyasol
Chemical Name: 4-[(1E,3R)-3-(4-hydroxyphenyl)penta-1,4-dienyl]phenol
CAS Number: 96895-25-9
Molecular Formula: C₁₇H₁₆O₂
Molecular Weight: 252.31
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-10-06 08:49:27
Modify Date: 2024-01-29 09:00:07
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells[1][2].

Name	4-[(1E,3R)-3-(4-hydroxyphenyl)penta-1,4-dienyl]phenol
Synonyms	4,4'-(3-Ethenyl-1-propene-1,3-diyl)-bisphenol (+)-hinokiresinol Nyasol

Description	Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Lim H, et al. (-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. Arch Pharm Res. 2009 Nov;32(11):1509-14. [2]. Iida Y, et al. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 2000 Jun;66(5):435-8. [3]. Lee HJ, et al. (-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells. J Enzyme Inhib Med Chem. 2013 Oct;28(5):954-9.