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138786-67-1

138786-67-1 structure
138786-67-1 structure
  • Name: Pantoprazole sodium
  • Chemical Name: Pantoprazole sodium
  • CAS Number: 138786-67-1
  • Molecular Formula: C16H14F2N3NaO4S
  • Molecular Weight: 405.35200
  • Catalog: API Digestive system medication Acid and gastric mucosal protective drugs
  • Create Date: 2018-02-05 08:00:00
  • Modify Date: 2024-01-02 09:15:08
  • Pantoprazole sodium salt(SKF96022; Protonix) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.IC50 value:Target: proton pump inhibitor
Name Pantoprazole sodium
Synonyms Pantoprazole
MFCD01658543
sodium 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide
Sodium 6-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide
Pantoprazole sodium
1H-Benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)
protium
Sodium 5-(difluoromethoxy)-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl}benzimidazol-1-ide
1H-benzimidazole, 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt
Protonix
5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium
1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)
Pantoprazole Sodium Salt
Pantoprazole (sodium)
Description Pantoprazole sodium salt(SKF96022; Protonix) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.IC50 value:Target: proton pump inhibitor
Related Catalog
References

[1]. http://www.drugbank.ca/drugs/DB00213
Boiling Point 586.9ºC at 760 mmHg
Melting Point 199-202ºC
Molecular Formula C16H14F2N3NaO4S
Molecular Weight 405.35200
Flash Point 308.7ºC
Exact Mass 405.05700
PSA 94.68000
LogP 3.53580
Storage condition -20°C Freezer
Material Safety Data Sheet
Section1. Identification of the substance
Product Name: Pantoprazole sodium
Synonyms:
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
Section3. Composition/information on ingredients.
Ingredient name:Pantoprazole sodium
CAS number:138786-67-1
Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C16H14F2N3NaO4S
Molecular weight:405.4
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride, sulfur oxides.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD8264000
CHEMICAL NAME :
1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)me thyl)sulfinyl)-, sodium salt
CAS REGISTRY NUMBER :
138786-67-1
LAST UPDATED :
199503
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H14-F2-N3-O4-S.Na
MOLECULAR WEIGHT :
405.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
747 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
256 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
395 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 15,801,1990
Hazard Codes Xn:Harmful
Risk Phrases R20/21/22-37/38-41-48
Safety Phrases S22-26-36/37/39-45
HS Code 2933990090
102625-70-7 structure

102625-70-7

~95%

138786-67-1 structure

138786-67-1

Literature: TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC. Patent: WO2004/111029 A2, 2004 ; Location in patent: Page 24 ;
102625-64-9 structure

102625-64-9

~97%

138786-67-1 structure

138786-67-1

Literature: MACLEODS PHARMACEUTICALS LIMITED Patent: WO2009/66317 A2, 2009 ; Location in patent: Page/Page column 8 ;
409098-86-8 structure

409098-86-8

~70%

138786-67-1 structure

138786-67-1

Literature: Napoletano, Caterina; Porta, Eleonora; Allegrini, Pietro; Castaldi, Graziano Patent: US2005/96352 A1, 2005 ; Location in patent: Page/Page column 4 ;
97963-62-7 structure

97963-62-7

72830-09-2 structure

72830-09-2

~82%

138786-67-1 structure

138786-67-1

Literature: CIPLA LIMITED; WAIN, Christopher, Paul Patent: WO2006/64249 A2, 2006 ; Location in patent: Page/Page column 8; 10 ;
368890-20-4 structure

368890-20-4

124-41-4 structure

124-41-4

~69%

138786-67-1 structure

138786-67-1

Literature: Dipharma S.p.A. Patent: EP1518857 A1, 2005 ; Location in patent: Page/Page column 5-6 ;
1310-73-2 structure

1310-73-2

102625-70-7 structure

102625-70-7

~%

138786-67-1 structure

138786-67-1

Literature: WO2008/45777 A2, ; Page/Page column 27-28 ;
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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