145158-71-0
145158-71-0 structure
- Name: Tegaserod
- Chemical Name: tegaserod
- CAS Number: 145158-71-0
- Molecular Formula: C16H23N5O
- Molecular Weight: 301.387
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-07-14 19:44:24
- Modify Date: 2024-01-02 14:50:14
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Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1].
| Name | tegaserod |
|---|---|
| Synonyms |
(2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide
Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2E)- tegaserodum (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide Zelmac MFCD06660144 Tegaserode (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N'-pentylhydrazinecarboximidamide Tegaserod |
| Description | Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1]. |
|---|---|
| Related Catalog | |
| Target |
5-HT4 Receptor |
| In Vitro | Tegaserod (1.5 and 3 μM) induces apoptosis in the B16F10 murine melanoma cell line as well as several human melanoma cell lines[1]. Cell Viability Assay[1] Cell Line: B16F10 cells Concentration: 78 nM-10 μM Incubation Time: 72 hours Result: Had anti-cancer activity with IC50 values in the low micromolar range as assessed by MTT assay following 72 h of exposure. |
| In Vivo | Tegaserod (5 mg/kg) delays tumor growth, reduces metastases, increases survival and suppresses p-S6 in vivo[1]. Animal Model: C57BL/6 J mice were subcutaneously injected with B16F10 cells[1] Dosage: 5 mg/kg Administration: Administered intraperitoneally (i.p.) daily for five consecutive days Result: Treatment significantly decreased tumor growth and resulted in only slight decreases in weight following treatment. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 470.6±48.0 °C at 760 mmHg |
| Melting Point | 180-183ºC |
| Molecular Formula | C16H23N5O |
| Molecular Weight | 301.387 |
| Flash Point | 238.4±29.6 °C |
| Exact Mass | 301.190247 |
| PSA | 159.89000 |
| LogP | 2.91 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.597 |
|
~%
145158-71-0 |
| Literature: WO2005/14544 A1, ; Page/Page column 10-11 ; |
|
~90%
145158-71-0 |
| Literature: EP1955998 A1, ; Page/Page column 3 ; |
| Precursor 3 | |
|---|---|
| DownStream 1 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |