Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tegaserod
Price:
Purity: 99.89%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: Tegaserod
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

145158-71-0

145158-71-0 structure

145158-71-0 structure

Name: Tegaserod
Chemical Name: tegaserod
CAS Number: 145158-71-0
Molecular Formula: C₁₆H₂₃N₅O
Molecular Weight: 301.387
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-07-14 19:44:24
Modify Date: 2024-01-02 14:50:14
Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1].

Name	tegaserod
Synonyms	(2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2E)- tegaserodum (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide Zelmac MFCD06660144 Tegaserode (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N'-pentylhydrazinecarboximidamide Tegaserod

Description	Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT4 Receptor
In Vitro	Tegaserod (1.5 and 3 μM) induces apoptosis in the B16F10 murine melanoma cell line as well as several human melanoma cell lines[1]. Cell Viability Assay[1] Cell Line: B16F10 cells Concentration: 78 nM-10 μM Incubation Time: 72 hours Result: Had anti-cancer activity with IC50 values in the low micromolar range as assessed by MTT assay following 72 h of exposure.
In Vivo	Tegaserod (5 mg/kg) delays tumor growth, reduces metastases, increases survival and suppresses p-S6 in vivo[1]. Animal Model: C57BL/6 J mice were subcutaneously injected with B16F10 cells[1] Dosage: 5 mg/kg Administration: Administered intraperitoneally (i.p.) daily for five consecutive days Result: Treatment significantly decreased tumor growth and resulted in only slight decreases in weight following treatment.
References	[1]. Wei Liu, et al. Repurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications. J Exp Clin Cancer Res. 2020 Feb 21;39(1):38.

Density	1.2±0.1 g/cm3
Boiling Point	470.6±48.0 °C at 760 mmHg
Melting Point	180-183ºC
Molecular Formula	C₁₆H₂₃N₅O
Molecular Weight	301.387
Flash Point	238.4±29.6 °C
Exact Mass	301.190247
PSA	159.89000
LogP	2.91
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.597

Hazard Codes	Xi
Risk Phrases	R20/21/22
Safety Phrases	S36/37
HS Code	2933990090

843609-64-3 structure

843609-64-3

~%

145158-71-0 structure

145158-71-0

Literature: WO2005/14544 A1, ; Page/Page column 10-11 ;

10601-19-1 structure

10601-19-1

1043452-36-3 structure

1043452-36-3

~90%

145158-71-0 structure

145158-71-0

Literature: EP1955998 A1, ; Page/Page column 3 ;

Precursor 3
843609-64-3 10601-19-1 1043452-36-3
DownStream 1
189188-57-6

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%