Tegaserod
Modify Date: 2024-01-02 14:50:14
Tegaserod structure
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Common Name | Tegaserod | ||
|---|---|---|---|---|
| CAS Number | 145158-71-0 | Molecular Weight | 301.387 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 470.6±48.0 °C at 760 mmHg | |
| Molecular Formula | C16H23N5O | Melting Point | 180-183ºC | |
| MSDS | N/A | Flash Point | 238.4±29.6 °C | |
Use of TegaserodTegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1]. |
| Name | tegaserod |
|---|---|
| Synonym | More Synonyms |
| Description | Tegaserod is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Anti-tumor activity[1]. |
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| Related Catalog | |
| Target |
5-HT4 Receptor |
| In Vitro | Tegaserod (1.5 and 3 μM) induces apoptosis in the B16F10 murine melanoma cell line as well as several human melanoma cell lines[1]. Cell Viability Assay[1] Cell Line: B16F10 cells Concentration: 78 nM-10 μM Incubation Time: 72 hours Result: Had anti-cancer activity with IC50 values in the low micromolar range as assessed by MTT assay following 72 h of exposure. |
| In Vivo | Tegaserod (5 mg/kg) delays tumor growth, reduces metastases, increases survival and suppresses p-S6 in vivo[1]. Animal Model: C57BL/6 J mice were subcutaneously injected with B16F10 cells[1] Dosage: 5 mg/kg Administration: Administered intraperitoneally (i.p.) daily for five consecutive days Result: Treatment significantly decreased tumor growth and resulted in only slight decreases in weight following treatment. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 470.6±48.0 °C at 760 mmHg |
| Melting Point | 180-183ºC |
| Molecular Formula | C16H23N5O |
| Molecular Weight | 301.387 |
| Flash Point | 238.4±29.6 °C |
| Exact Mass | 301.190247 |
| PSA | 159.89000 |
| LogP | 2.91 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.597 |
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~%
Tegaserod CAS#:145158-71-0 |
| Literature: WO2005/14544 A1, ; Page/Page column 10-11 ; |
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~90%
Tegaserod CAS#:145158-71-0 |
| Literature: EP1955998 A1, ; Page/Page column 3 ; |
CAS#:189188-57-6| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| (2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide |
| Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2E)- |
| tegaserodum |
| (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide |
| Zelmac |
| MFCD06660144 |
| Tegaserode |
| (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N'-pentylhydrazinecarboximidamide |
| Tegaserod |