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16773-42-5

16773-42-5 structure
16773-42-5 structure
  • Name: Ornidazole
  • Chemical Name: ornidazole
  • CAS Number: 16773-42-5
  • Molecular Formula: C7H10ClN3O3
  • Molecular Weight: 219.626
  • Catalog: API Antiparasitic drug Anti-amebiasis and anti-trichomoniasis drugs
  • Create Date: 2018-06-19 03:01:05
  • Modify Date: 2024-01-02 13:50:10
  • Ornidazole(Ro 7-0207) is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Target: Antibacterial; AntiparasiticOrnidazole is a drug that cures some protozoan infections. Ornidazole 1 g/day is effective for the prevention of recurrence of Crohn's disease after ileocolonic resection [1]. Ornidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms [2].
Name ornidazole
Synonyms 1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole
α-(Chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol
α-(Chloromethyl)-2-methyl-5-nitroimidazole-1-ethanol
UNII:62XCK0G93T
Imidazole-1-ethanol, α- (chloromethyl)-2-methyl-5-nitro-
Ornidazole
1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
Imidazole-1-ethanol, α-(chloromethyl)-2-methyl-5-nitro-
α-(Chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol (9CI)
MFCD00057960
1-Chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)-2-propanol
1H-Imidazole-1-ethanol, α-(chloromethyl)-2-methyl-5-nitro-
a-(Chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol
1H-Imidazole-1-ethanol, α- (chloromethyl)-2-methyl-5-nitro-
1-chloro-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol
EINECS 240-826-0
Description Ornidazole(Ro 7-0207) is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Target: Antibacterial; AntiparasiticOrnidazole is a drug that cures some protozoan infections. Ornidazole 1 g/day is effective for the prevention of recurrence of Crohn's disease after ileocolonic resection [1]. Ornidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms [2].
Related Catalog
References

[1]. Rutgeerts, P., et al., Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology, 2005. 128(4): p. 856-61.

[2]. Goldstein, E.J., V.L. Sutter, and S.M. Finegold, Comparative susceptibilities of anaerobic bacteria to metronidazole, ornidazole, and SC-28538. Antimicrob Agents Chemother, 1978. 14(4): p. 609-13.
Density 1.5±0.1 g/cm3
Boiling Point 443.2±40.0 °C at 760 mmHg
Melting Point 85-90°C
Molecular Formula C7H10ClN3O3
Molecular Weight 219.626
Flash Point 221.9±27.3 °C
Exact Mass 219.041061
PSA 83.87000
LogP 0.69
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.617
Storage condition -20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI5460000
CHEMICAL NAME :
Imidazole-1-ethanol, alpha-(chloromethyl)-2-methyl-5-nitro-
CAS REGISTRY NUMBER :
16773-42-5
BEILSTEIN REFERENCE NO. :
0614299
LAST UPDATED :
199612
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C7-H10-Cl-N3-O3
MOLECULAR WEIGHT :
219.65
WISWESSER LINE NOTATION :
T5N CNJ A1YQ1G B1 ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1139 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
375 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
36400 mg/kg/13W-C
TOXIC EFFECTS :
Related to Chronic Data - changes in prostate weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
6500 mg/kg/26D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
292 gm/kg/2Y-C
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
25600 mg/kg
SEX/DURATION :
male 64 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
35 gm/kg
SEX/DURATION :
male 61 day(s) pre-mating female 14 day(s) pre-mating - 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
11200 mg/kg
SEX/DURATION :
male 4 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
5600 mg/kg
SEX/DURATION :
male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

MUTATION DATA

TYPE OF TEST :
Host-mediated assay
TEST SYSTEM :
Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION :
50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 86,243,1981
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS NI5460000
HS Code 2933290090
Precursor  1

DownStream  2

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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