Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Chloramine-T trihydrate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

7080-50-4

7080-50-4 structure

Name: Chloramine-T trihydrate
Chemical Name: Chloramine-T trihydrate
CAS Number: 7080-50-4
Molecular Formula: C₇H₁₃ClNNaO₅S
Molecular Weight: 281.690
Catalog: analytical chemistry Analytical reagent Common analytical reagents
Create Date: 2018-06-08 11:33:50
Modify Date: 2024-01-04 18:29:11
Tosylchloramide sodium trihydrate (Chloramine T sodium trihydrate) is a disinfectant agent widely used in laboratories, kitchens and hospitals. It is also used as a biocide in air fresheners and deodorants.

Name	Chloramine-T trihydrate
Synonyms	N-chloro-toluene-4-sulfonamide,sodium salt Chloramine-T trihydrate MFCD00149066 TOSYLCHLORAMIDE SODIUM TRIHYDRATE ChloraMine T&chloroamine T trihydrate sodium chloro[(4-methylphenyl)sulfonyl]azanide trihydrate CHLORAMINE T GR CHLORAMINE T 3-HYDRATE CHLORAMINE T TRIHYDRATE N-Chloro-p-toluenesulfonamide sodium salt trihydrate chloramine T hydratee CHLOROMINE-T SOLUTION Sodium chloro[(4-methylphenyl)sulfonyl]azanide hydrate (1:1:3) Chloroamine t trihydrate Benzenesulfonamide, N-chloro-4-methyl-, sodium salt, hydrate (1:1:3) CHLOROAMINUM Chloramine-T,Sodium salt EINECS 204-854-7

Description	Tosylchloramide sodium trihydrate (Chloramine T sodium trihydrate) is a disinfectant agent widely used in laboratories, kitchens and hospitals. It is also used as a biocide in air fresheners and deodorants.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
In Vitro	Gram-positive growth is reduced by 95% to 100% after tosylchloramide treatment, regardless of dose, with or without serum. E coli (gram-negative; with/without serum) is reduced 94% to 100% at antiseptic concentrations of 300 and 400 ppm. At 200 ppm, E coli growth is fully inhibited without serum present and by 50% with serum. At 100 and 200 ppm, cell viability remains greater than 90% under all experimental conditions. A 300-ppm, 3-minute exposure to tosylchloramide results in cell viability of up to 70%, with longer exposures producing lower viabilities. Serum does not affect cell viability in any condition[1].
In Vivo	A dose-dependently significant DNA damage in the rat tissues and inflammation is histopathologically noted around the terminal airways of the lung in both male and female rats[2]. The 24-h exposure to 50 mg/L of chloramine-T is toxic for crayfish and leads to substantial loss of energy that became apparent during subsequently conducted physical stress[3]. Tosylchloramide may potentiate the toxicity of many xenobiotics via metabolic activation and/or accumulation of reactive metabolites. The activities of CYP2E1, CYP1A1/2 CYP2B1/2, CYP3A4 and CYP4A1/2 enzymes significantly increase after treatment with 2.50, 5 and 10 mg/kg bw/day tosylchloramide, in a dose-dependent manner. This effect is not observed after tosylchloramide treatment at dose of 1.25 mg/kg bw/day[4].
Animal Admin	Rats: Male and female groups of rats are exposed to tosylchloramide at concentrations of 0.2, 0.9 and 4 mg/m3 for 6 hr/day, 5 days/week during 4 weeks. All rats are sacrificed after treatment for 4 weeks[2].
References	[1]. Kloth LC, et al. Bactericidal and cytotoxic effects of chloramine-T on wound pathogens and human fibroblasts in vitro. Adv Skin Wound Care. 2007 Jun;20(6):331-45. [2]. Shim I, et al. Inhalation exposure to chloramine T induces DNA damage and inflammation in lung of Sprague-Dawley rats. J Toxicol Sci. 2013;38(6):937-46. [3]. Kuklina I, et al. Investigation of chloramine-T impact on crayfish Astacus leptodactylus (Esch., 1823) cardiac activity. Environ Sci Pollut Res Int. 2014 Sep;21(17):10262-9. [4]. Martínez MA, et al. Induction of cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation by chloramine-T in male rat liver. Food Chem Toxicol. 2017 Aug;106(Pt A):86-91.

Melting Point	167-170 °C(lit.)
Molecular Formula	C₇H₁₃ClNNaO₅S
Molecular Weight	281.690
Flash Point	92 °C
Exact Mass	281.010071
PSA	70.21000
LogP	3.09910
Storage condition	0-6°C

Symbol	GHS05, GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H314-H334
Supplemental HS	Contact with acids liberates toxic gas.
Precautionary Statements	P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C:Corrosive
Risk Phrases	R22;R31;R34;R42
Safety Phrases	S22-S26-S36/37/39-S45
RIDADR	UN 3263 8/PG 3
WGK Germany	2
RTECS	XT5616800
Packaging Group	III
Hazard Class	8

Precursor 2
70-55-3 473-34-7
DownStream 10
60577-30-2 93008-98-1 83-33-0 609-23-4
1003-57-2 563-84-8 760-86-1 76475-10-0
70-55-3 138-41-0

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