Name | H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH |
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Synonyms |
Apelin-12 (huMan,bovine,Mouse,rat) (Des-Gln1)-Apelin-13 (huMan,bovine,Mouse,rat),Apelin Precursor (66-77) (huMan,bovine,Mouse,rat),Preproapelin (66-77) (huMan,bovine,Mouse,rat)
APELIN PRECURSOR (66-77) (HUMAN,BOVINE,MOUSE,RAT) ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE APELIN 12 (DES-GLN1)-APELIN-13 (HUMAN,BOVINE,MOUSE,RAT) (Des-Gln1)-Apelin-13 (huMan,bovine,Mouse,rat),Apelin Precursor (66-77) (huMan,bovine,Mouse,rat),Preproapelin (66-77) (huMan,bovine,Mouse,rat) RPRLSHKGPMPF APELIN-12 (HUMAN,BOVINE,MOUSE,RAT) H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH PREPROAPELIN (66-77) (HUMAN,BOVINE,MOUSE,RAT) |
Description | Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3]. |
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Related Catalog | |
In Vitro | Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse[1]. Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents[2]. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs[4]. |
References |
Molecular Formula | C64H103N21O14S |
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Molecular Weight | 1422.70000 |
Exact Mass | 1421.77000 |
PSA | 581.08000 |
LogP | 2.26000 |
Storage condition | -20°C |