23243-68-7

23243-68-7 structure

Name: 3,6-Dioxaoctanedioic acid
Chemical Name: 2-[2-(carboxymethoxy)ethoxy]acetic acid
CAS Number: 23243-68-7
Molecular Formula: C₆H₁₀O₆
Molecular Weight: 178.14000
Catalog: Chemical reagent Organic reagent fatty acid
Create Date: 2018-06-30 09:41:23
Modify Date: 2024-01-02 18:52:30
36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-(carboxymethoxy)ethoxy]acetic acid
Synonyms	2,2'-(ethane-1,2-diylbis(oxy))diacetic acid 3,6-dioxaoctadioic acid 3,6-dioxoctanedioic acid 3,6-dioxa-1,8-octanedioic acid 3,6-dioxaoctane-1,8-dioic acid 3,6-DIOXAOCTANEDIOIC ACID (2-carboxymethoxyethoxy)acetic acid 3,6-dioxaoctandioic acid

Description	36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

112-27-6

~95%

23243-68-7

Literature: Kuroboshi, Manabu; Yoshida, Tomonori; Oshitani, Jun; Goto, Kuniaki; Tanaka, Hideo Tetrahedron, 2009 , vol. 65, # 34 p. 7177 - 7185

112-60-7

~16%

110-99-6

23243-68-7

13887-98-4

Literature: Tetrahedron, , vol. 38, # 22 p. 3299 - 3308

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%