Name | methyl N-[2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethyl]carbamate |
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Synonyms |
Pamatolol [INN]
Pamatololum [INN-Latin] Pamatololum UNII-20G2S6V53L Pamatolol Methyl N-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenethyl)carbamat |
Description | Pamatolol is a cardioselective beta-adrenoceptor antagonist without sympathomimetic activity. |
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Related Catalog | |
In Vivo | Pamatolol is well absorbed in the gastro-intestinal tract and excreted in the urine of man, dogs, rats and mice after oral administration, mainly in unchanged form, within 24 hrs[1]. |
Animal Admin | Three male Sprague-Dawley rats weighing 200-250 g are given pamatolol-sulphate dissolved in water at a dose of 50 mg/kg (10 μCi/mg) by means of a stomach tube. The rats are housed in metabolic cages that allows for separate collection of urine and feces for a 24 hr period. They are given a commercial pellet diet and drinking water ad libitum. |
References |
Density | 1.103g/cm3 |
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Boiling Point | 487ºC at 760 mmHg |
Molecular Formula | C16H26N2O4 |
Molecular Weight | 310.38900 |
Flash Point | 248.3ºC |
Exact Mass | 310.18900 |
PSA | 79.82000 |
LogP | 2.10460 |
Index of Refraction | 1.518 |
Storage condition | 2-8℃ |