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144-29-6

144-29-6 structure
144-29-6 structure
  • Name: Piperazine citrate
  • Chemical Name: Piperazine Citrate
  • CAS Number: 144-29-6
  • Molecular Formula: C6H8O7.3/2C4H10N2
  • Molecular Weight: 321.33
  • Catalog: Pharmaceutical intermediate Heterocyclic compound Piperazine
  • Create Date: 2018-10-02 17:00:46
  • Modify Date: 2024-01-02 21:52:02
  • Piperazine Citrate is an organic compound that consists of a six-membered ring, containting two nitrogen atoms at opposite positions in the ring; first introduced in 1953 as an Anthelmintic.

Name Piperazine Citrate
Synonyms citric acid sesquipiperazine salt
Oxucide
Anthecole
Oxyzine
EINECS 205-622-8
Coliurinal
Antoban
Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2) (salt)
Piperazine 2-hydroxy-1,2,3-propanetricarboxylate (3:2)
Exelmin
RHOMEX
PiperazineCitrateBp
Helmezine
Exopin
Parazine
Vermizine (elixir)
Vermago
Piperazin,Cirate
Nemadital
Pin-Tega
Tripiperazindicitrat
Piperazine 2-hydroxypropane-1,2,3-tricarboxylate (3:2)
tripiperazine dicitrate
Ascarex Syrup
Citraazine
Piperazincitrat
piperazine,cirate
MFCD00038961
Pinozan
ANTEPAR
Pipizan
Piperazine Citrate
UNII:RI85381D5G
Piperasol
Patazine
Ta-Verm
Piperazine (citrate)
Description Piperazine Citrate is an organic compound that consists of a six-membered ring, containting two nitrogen atoms at opposite positions in the ring; first introduced in 1953 as an Anthelmintic.
Related Catalog
Boiling Point 812.2ºC
Melting Point 183-187ºC
Molecular Formula C6H8O7.3/2C4H10N2
Molecular Weight 321.33
Flash Point 445ºC
PSA 336.44000

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL3485000
CAS REGISTRY NUMBER :
144-29-6
LAST UPDATED :
199706
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C12-H30-N6.C12-H16-O14
MOLECULAR WEIGHT :
642.76
WISWESSER LINE NOTATION :
T6M DMTJ & 3 &622 &QV1XQVQ1VQ & 2 &621

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
260 mg/kg/3D-I
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - coma Behavioral - headache
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,895,1967
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
150 mg/kg/5D
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - diplopia Behavioral - tremor Gastrointestinal - nausea or vomiting
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 161,515,1956
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
500 mg/kg/2D
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
REFERENCE :
INPDAR Indian Pediatrics. (Dept. of Pediatrics, Safdarjang Hospital, New Delhi 110029, India) V.1- 1964- Volume(issue)/page/year: 18,71,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,336,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,336,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3548 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Skin and Appendages - sweating
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 274,253,1985
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80482 No. of Facilities: 872 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3575 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80482 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 146 (estimated) No. of Female Employees: 23 (estimated)
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26
WGK Germany 1
RTECS TL3485000
HS Code 2942000000
HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%