CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
TL3485000
-
CAS REGISTRY NUMBER :
-
144-29-6
-
LAST UPDATED :
-
199706
-
DATA ITEMS CITED :
-
11
-
MOLECULAR FORMULA :
-
C12-H30-N6.C12-H16-O14
-
MOLECULAR WEIGHT :
-
642.76
-
WISWESSER LINE NOTATION :
-
T6M DMTJ & 3 &622 &QV1XQVQ1VQ & 2 &621
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - child
-
DOSE/DURATION :
-
260 mg/kg/3D-I
-
TOXIC EFFECTS :
-
Behavioral - muscle weakness Behavioral - coma Behavioral - headache
-
REFERENCE :
-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,895,1967
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - man
-
DOSE/DURATION :
-
150 mg/kg/5D
-
TOXIC EFFECTS :
-
Sense Organs and Special Senses (Eye) - diplopia Behavioral - tremor Gastrointestinal - nausea or vomiting
-
REFERENCE :
-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 161,515,1956
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Human - infant
-
DOSE/DURATION :
-
500 mg/kg/2D
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
-
REFERENCE :
-
INPDAR Indian Pediatrics. (Dept. of Pediatrics, Safdarjang Hospital, New Delhi 110029, India) V.1- 1964- Volume(issue)/page/year: 18,71,1981
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
11200 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
-
REFERENCE :
-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,336,1963
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
8500 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
-
REFERENCE :
-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,336,1963
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
3548 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - excitement Skin and Appendages - sweating
-
REFERENCE :
-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 274,253,1985
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
100 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
175 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80482 No. of Facilities: 872 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3575 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80482 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 146 (estimated) No. of Female Employees: 23 (estimated)
|