206052-02-0
206052-02-0 structure
- Name: MS-PPOH
- Chemical Name: N-methylsulfonyl-6-(2-propoxyphenyl)hexanamide
- CAS Number: 206052-02-0
- Molecular Formula: C16H25NO4S
- Molecular Weight: 327.439
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2016-01-12 23:01:30
- Modify Date: 2024-01-09 21:28:02
-
MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor[1]. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 µM, respectively[2].
| Name | N-methylsulfonyl-6-(2-propoxyphenyl)hexanamide |
|---|---|
| Synonyms |
Benzenehexanamide, N-(methylsulfonyl)-2-propoxy-
N-(Methylsulfonyl)-6-(2-propoxyphenyl)hexanamide |
| Description | MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor[1]. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 µM, respectively[2]. |
|---|---|
| Related Catalog | |
| In Vitro | MS-PPOH blocks cellular EET synthesis. MS-PPOH inhibits tonic (basal) cell invasion and migration and reduces the 11,12-EET (1.0 μM)-induced cell motility[1]. Cell Viability Assay[1] Cell Line: PC-3 cells Concentration: 2.0 and 10.0 μM Incubation Time: 24 hours Result: Inhibited tonic (basal) cell invasion and migration. |
| In Vivo | MS-PPOH (20 mg/kg/day, i.v.) for 6 days significantly reduced renal levels of epoxyeicosatrienoic acids (EETs) in Dahl salt-resistant rats on 2% NaCl drinking solution[3]. Animal Model: Six-week-old male stroke-prone spontaneously hypertensive rats (SHRSP)[3] Dosage: 20 mg/kg/day Administration: Intravenously Result: Treatment had negligible effects on systolic blood pressure (SBP) in saline-drinking SHRSP after 1 week, 160 vs. 167 mmHg, or 2 weeks of treatment, 171 vs. 175 mmHg, for vehicle vs. MS-PPOH, respectively. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Molecular Formula | C16H25NO4S |
| Molecular Weight | 327.439 |
| Exact Mass | 327.150421 |
| PSA | 84.34000 |
| LogP | 3.16 |
| Index of Refraction | 1.517 |