331467-05-1

331467-05-1 structure

Name: Indirubin-3'-monoxime-5-sulphonic acid
Chemical Name: 3-[3-(hydroxyamino)-1H-indol-2-yl]-2-oxoindole-5-sulfonic acid
CAS Number: 331467-05-1
Molecular Formula: C₁₆H₁₁N₃O₅S
Molecular Weight: 357.34
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2017-12-16 20:05:33
Modify Date: 2024-01-28 10:11:29
Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].

Name	3-[3-(hydroxyamino)-1H-indol-2-yl]-2-oxoindole-5-sulfonic acid
Synonyms	3-[3-(Hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid indirubin-3'-monoxime-5-sulphonic acid A05-A11B1-II

Description	Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	CDK1:5 nM (IC50) CDK5:7 nM (IC50) GSK-3β:80 nM (IC50)
References	[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60.