199119-18-1

199119-18-1 structure

Name: T 98475
Chemical Name: Isopropyl 3-{[benzyl(methyl)amino]methyl}-7-(2,6-difluorobenzyl)- 2-[4-(isobutyrylamino)phenyl]-4-oxo-4,7-dihydrothieno[2,3-b]pyrid ine-5-carboxylate
CAS Number: 199119-18-1
Molecular Formula: C₃₇H₃₇F₂N₃O₄S
Molecular Weight: 657.77
Catalog: Research Areas Endocrinology
Create Date: 2018-12-05 18:57:41
Modify Date: 2024-01-18 10:49:50
T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM[1].

Name	Isopropyl 3-{[benzyl(methyl)amino]methyl}-7-(2,6-difluorobenzyl)- 2-[4-(isobutyrylamino)phenyl]-4-oxo-4,7-dihydrothieno[2,3-b]pyrid ine-5-carboxylate

Description	T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
Target	IC50: 0.2 nM (human LHRH receptor), 2 nM (monkey LHRH receptor), 4 nM (monkey anterior pituitaries), 60 nM (rat anterior pituitaries)[1]
References	[1]. Imada T, et al. Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3809-25.