71861-76-2
71861-76-2 structure
- Name: 1-Acetyl-3-o-toluyl-5-fluorouracil
- Chemical Name: 1-acetyl-5-fluoro-3-(2-methylbenzoyl)pyrimidine-2,4-dione
- CAS Number: 71861-76-2
- Molecular Formula: C14H11FN2O4
- Molecular Weight: 290.24700
- Catalog: Research Areas Cancer
- Create Date: 2017-07-08 20:29:01
- Modify Date: 2024-01-10 18:09:27
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1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.
| Name | 1-acetyl-5-fluoro-3-(2-methylbenzoyl)pyrimidine-2,4-dione |
|---|---|
| Synonyms |
A-OT
1-Acetyl-5-fluoro-3-(2-methylbenzoyl)-2,4-(1H,3H)-pyrimidinedione N(sub 1)-Acetyl-N(sub 3)-o-toluyl-5-fluorouracil Atofluding 1-Acetyl-3,2-toluyl-5-fluorouracil 2,4(1H,3H)-Pyrimidinedione,1-acetyl-5-fluoro-3-(2-methylbenzoyl) 1-Acetyl-3-o-toluyl-5-fluorouracil |
| Description | 1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent. |
|---|---|
| Related Catalog | |
| In Vivo | Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d)[1]. |
| Animal Admin | Mice: Of the ten groups of tumor bearing mice, subcutaneous administration of 5-fluorouracil or 1-Acetyl-3-o-toluyl-5-fluorouracil is made at a dose of 0.2, 0.4 and 0.6 mmol/kg/d on six groups in the buttock region. In three groups, oil solution of 1-Acetyl-3-o-toluyl-5-fluorouracil is administered orally with a stomach tube at a dose of 0.2, 0.4 and 0.6 mmol/kg/d. The remaining group is used as tumor bearing control. During the period of the experiment, body weight is measured every 3 day and the long and short diameters of the tumor are measured daily[1]. |
| References |
| Density | 1.44g/cm3 |
|---|---|
| Boiling Point | 408.8ºC at 760 mmHg |
| Molecular Formula | C14H11FN2O4 |
| Molecular Weight | 290.24700 |
| Flash Point | 201.1ºC |
| Exact Mass | 290.07000 |
| PSA | 78.14000 |
| LogP | 0.80610 |
| Index of Refraction | 1.609 |
| Storage condition | 2-8℃ |