Name | psoralen |
---|---|
Synonyms |
Furocoumarin
7H-Furo[3,2-g]chromen-7-one Psoralen EINECS 200-639-7 Psoralene prosuler 6,7-Furanocoumarin MFCD00010520 Psorline-P FICUSIN 7H-Furo[3,2-g][1]benzopyran-7-one |
Description | Psoralen(Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity.IC50 value:Target:in vitro: Psoralen dosages of 1-10 μM exhibited low cytotoxicity toward chondrocytes. However, a dosage of 100 μM suppressed the proliferation of chondrocytes. Different concentrations of psoralen treatments on chondrocytes revealed that GAG and Type II collagen synthesis increased, especially at 100 μM, by 0.39-fold and 0.48-fold, respectively, on day 3, and by 0.51-fold and 0.56-fold, respectively, on day 9 [1]. in vivo: Tumor volume inhibition rates were 43.75% and 40.18%, respectively, in the psoralen and isopsoralen low-dose groups, and tumor weight inhibition rates were 38.83% and 37.77%. Tumor volume inhibition rates were 67.86% and 66.96%, respectively, in the psoralen and isopsoralen high-dose groups, and tumor weight inhibition rates were 49.47% and 47.87% [2]. psoralen can inhibit metastasis of breast cancer to bone in vivo. Histological, molecular biological, and imaging analyses revealed that psoralen inhibits bone metastases in mice [3]. |
---|---|
Related Catalog | |
References |
Density | 1.4±0.1 g/cm3 |
---|---|
Boiling Point | 362.6±27.0 °C at 760 mmHg |
Melting Point | 160-162 °C |
Molecular Formula | C11H6O3 |
Molecular Weight | 186.163 |
Flash Point | 173.1±23.7 °C |
Exact Mass | 186.031693 |
PSA | 43.35000 |
LogP | 1.67 |
Vapour Pressure | 0.0±0.8 mmHg at 25°C |
Index of Refraction | 1.667 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
|
Symbol |
GHS07 |
---|---|
Signal Word | Warning |
Hazard Statements | H302-H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn:Harmful; |
Risk Phrases | R36/37/38 |
Safety Phrases | S26 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | LV0944000 |
Precursor 9 | |
---|---|
DownStream 4 | |