Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: isoetarine
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Purity: 98.0%
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530-08-5

530-08-5 structure

Name: isoetarine
Chemical Name: 4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol
CAS Number: 530-08-5
Molecular Formula: C₁₃H₂₁NO₃
Molecular Weight: 239.31100
Catalog: API Respiratory medication Asthma
Create Date: 2018-06-07 11:03:30
Modify Date: 2024-01-02 16:39:45
Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like drug and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator[1][2].

Name	4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol
Synonyms	Isoetarina isoetharine Isoetarine Bronkosol Isoetarin Etyprenalinum 1-(3,4-dihydroxy-phenyl)-2-isopropylamino-butan-1-ol Etyprenaline Dilabron Bronkometer Isoetarinum

Description	Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like drug and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
In Vitro	Isoetharine (50 μM, 18 hours) can induce the production and release of [35S]sulfated metabolites of catecholic drugs in HepG2 human hepatoma cells[1].
In Vivo	Isoetharine inhibits melanin deposition with the AC50 value of 5.10 mM and complete inhibition of pigment production at 7.50 mM in the zebrafish larvae model[2].
References	[1]. Katsuhisa Kurogi，et al. Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs. Biochem Pharmacol. 2012 Nov 1;84(9):1186-95. [2]. Monika Maciag，et al. Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish. Toxicol Appl Pharmacol. 2022 Jan 1;434:115812.

Molecular Formula	C₁₃H₂₁NO₃
Molecular Weight	239.31100
Exact Mass	239.15200
PSA	72.72000
LogP	2.29870

HS Code	2922509090

75-31-0

530-08-5

Literature: Winthrop Chem.Co. Patent: US2083001 , 1935 ; Full Text Show Details I.G.Farbenind. Patent: DE638650 , 1934 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 486

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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