485-63-2

485-63-2 structure

Name: 3',4',7-trihydroxy isoflavone
Chemical Name: 3',4',7-trihydroxyisoflavone
CAS Number: 485-63-2
Molecular Formula: C₁₅H₁₀O₅
Molecular Weight: 270.24
Catalog: Biochemical Plant extracts
Create Date: 2018-09-12 20:33:32
Modify Date: 2024-01-03 00:15:34
7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].

Name	3',4',7-trihydroxyisoflavone
Synonyms	7,3',4'-THIF 3-(3,4-Dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one 3',4',7-Trihydroxyisoflavone 3`,4`,7-Trihydroxyisoflavone 4H-1-Benzopyran-4-one, 3-(3,4-dihydroxyphenyl)-7-hydroxy- 3l5r MFCD00143002 3-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-on 3',4',7-trihydroxy isoflavone 3'-Hydroxydaidzein 3-(3,4-dihydroxyphenyl)-7-hydroxychromen-4-one 3-(3,4-dihydroxy-phenyl)-7-hydroxy-chromen-4-one 7,3',4'-Trihydroxyisoflavone 7-Hydroxy-3-(3,4-dihydroxyphenyl)-4H-chromen-4-one 4H-1-Benzopyran-4-one,3-(3,4-dihydroxyphenyl)-7-hydroxy

Description	7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> MAP3K
In Vitro	7,3',4'-Trihydroxyisoflavone triggers cell cycle arrest at the G1 phase and displays an anti-proliferative effect against EGF receptor-positive skin cancer[1]. 7,3',4'-Trihydroxyisoflavone also significantly inhibits UVB-induced COX-2 expression by suppressing the NF-B transcription activity in mouse skin epidermal JB6 P+ cells[1].
In Vivo	In a mouse skin tumorigenesis model, 7,3',4'-Trihydroxyisoflavone strongly suppresses the incidence, multiplicity, and volume of UVB-induced mouse skin tumors. Consistent with the tumor data, 7,3',4'-Trihydroxyisoflavone clearly attenuates UVB-induced COX-2 expression in hairless mouse skin[2].
References	[1]. Yu-Li Lo, et al. 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology. 2012 Dec 16;302(2-3):221-32. [2]. Dong Eun Lee, et al. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem. 2011 Apr 22;286(16):14246-56.