87828-86-2

87828-86-2 structure
87828-86-2 structure
  • Name: L-Leucine-d3
  • Chemical Name: (2S)-2-amino-5,5,5-trideuterio-4-methylpentanoic acid
  • CAS Number: 87828-86-2
  • Molecular Formula: C6H10D3NO2
  • Molecular Weight: 134.191
  • Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
  • Create Date: 2018-06-19 15:37:06
  • Modify Date: 2024-01-03 10:19:52
  • L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

Name (2S)-2-amino-5,5,5-trideuterio-4-methylpentanoic acid
Synonyms (S)-Leucine-d3
L-Leucine-5,5,5-d3
L-Leucine-5,5,5-d
L-(5,5,5-H)Leucine
MFCD00144628
L-|A-Aminoisocaproic Acid-d3
L-Leucine-d3
(S)-2-Amino-4-methylvaleric Acid-d3
L-2-Amino-4-methylpentanoic Acid-d3
Description L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Density 1.0±0.1 g/cm3
Boiling Point 225.8±23.0 °C at 760 mmHg
Melting Point >300ºC(lit.)
Molecular Formula C6H10D3NO2
Molecular Weight 134.191
Flash Point 90.3±22.6 °C
Exact Mass 134.113464
PSA 63.32000
LogP 0.73
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.463
Storage condition 2-8°C
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport