100823-03-8
100823-03-8 structure
- Name: TC11
- Chemical Name: 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione
- CAS Number: 100823-03-8
- Molecular Formula: C20H22N2O2
- Molecular Weight: 322.40100
- Catalog: Signaling Pathways Apoptosis Bcl-2 Family
- Create Date: 2017-01-19 04:15:00
- Modify Date: 2024-01-04 23:10:23
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TC11 is a MCL1 degradator and Caspase-9 and CDK1 activator. TC11 structurally relates to immunomodulatory drugs as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest[1][2].
| Name | 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione |
|---|---|
| Synonyms | 1H-Isoindole-1,3(2H)-dione,5-amino-2-[2,6-bis(1-methylethyl)phenyl] |
| Description | TC11 is a MCL1 degradator and Caspase-9 and CDK1 activator. TC11 structurally relates to immunomodulatory drugs as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest[1][2]. |
|---|---|
| Related Catalog | |
| Target |
CDK1 Caspase-9 MCL1 |
| In Vitro | Cell Viability Assay[1] Cell Line: KMS34 cells Concentration: 0~30 μM Incubation Time: 24 hours Result: Induced cell death. Western Blot Analysis[1] Cell Line: KMS34 cells Concentration: 5 μM Incubation Time: 0~48 hours Result: Induced cell death occurs through an apoptotic pathway and downregulated MCL1 expression. Cell Cycle Analysis[1] Cell Line: KMS34 cells Concentration: 5 μM Incubation Time: 24 hours Result: Induced M arrest. |
| In Vivo | TC11 (0~30 μM; 24 hours; KMS34 cells) induces cell death in KMS34[1]. TC11 (5 μM; 0~48 hours; KMS34 cells) induces cell death occurs through an apoptotic pathway and downregulates MCL1 expression[1]. TC11 (5 μM; 24 hours; KMS34 cells) induces M arrest[1]. |
| References |
| Molecular Formula | C20H22N2O2 |
|---|---|
| Molecular Weight | 322.40100 |
| Exact Mass | 322.16800 |
| PSA | 63.40000 |
| LogP | 4.96240 |
| Storage condition | 2-8°C |