934358-00-6
934358-00-6 structure
- Name: TBCA
- Chemical Name: 3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid
- CAS Number: 934358-00-6
- Molecular Formula: C9H4Br4O2
- Molecular Weight: 463.743
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
- Create Date: 2018-06-16 12:29:52
- Modify Date: 2024-01-05 12:48:14
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TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2].
| Name | 3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid |
|---|---|
| Synonyms |
(2E)-3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid
tetrabromocinnamic acid 2-Propenoic acid, 3-(2,3,4,5-tetrabromophenyl)-, (2E)- (2E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid |
| Description | TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2]. |
|---|---|
| Related Catalog | |
| Target |
CK2:110 nM (IC50) CK2:77 nM (Ki) |
| In Vitro | TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability[1]. TBCA also inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM[1]. TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including 2-MeSADP, AYPGKF, SFLLRN, and CRP. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF[2]. Cell Viability Assay[1] Cell Line: Jurkat cells Concentration: 0-100 μM Incubation Time: 24 hours Result: The viability of Jurkat cells was reduced. |
| References |
| Density | 2.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 490.8±45.0 °C at 760 mmHg |
| Molecular Formula | C9H4Br4O2 |
| Molecular Weight | 463.743 |
| Flash Point | 250.6±28.7 °C |
| Exact Mass | 459.694458 |
| PSA | 37.30000 |
| LogP | 5.28 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.714 |