21052-18-6

21052-18-6 structure

Name: 2’,3’,5’-Tri-O-benzoyl-2-thiouridine
Chemical Name: 2,3,5,-Tri-O-benzoyl-2-thiouridine
CAS Number: 21052-18-6
Molecular Formula: C₃₀H₂₄N₂O₈S
Molecular Weight: 572.59
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2017-05-13 06:06:03
Modify Date: 2024-01-04 17:58:46
2’,3’,5’-Tri-O-benzoyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	2,3,5,-Tri-O-benzoyl-2-thiouridine
Synonyms	[(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methyl benzoate

Description	2’,3’,5’-Tri-O-benzoyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

6974-32-9

141-90-2

~58%

21052-18-6

Literature: Vorbrueggen, Helmut; Bennua, Baerbel Chemische Berichte, 1981 , vol. 114, # 4 p. 1279 - 1286

6974-32-9

21052-18-6

Literature: El-Tayeb, Ali; Qi, Aidong; Nicholas, Robert A.; Mueller, Christa E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2878 - 2890