304008-29-5

304008-29-5 structure

Name: LU AA33810
Chemical Name: N-{[trans-4-(4,5-Dihydro[1]benzothiepino[5,4-d][1,3]thiazol-2-yla mino)cyclohexyl]methyl}methanesulfonamide
CAS Number: 304008-29-5
Molecular Formula: C₁₉H₂₅N₃O₂S₃
Molecular Weight: 423.61600
Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
Create Date: 2017-06-10 05:28:25
Modify Date: 2024-01-31 19:24:04
Lu AA33810 is a potent and selective antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the human receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects[1].

Name	N-{[trans-4-(4,5-Dihydro[1]benzothiepino[5,4-d][1,3]thiazol-2-yla mino)cyclohexyl]methyl}methanesulfonamide

Description	Lu AA33810 is a potent and selective antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the human receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
Target	hY5 receptor:1.5 nM (Ki)
References	[1]. Walker MW, et al. The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. J Pharmacol Exp Ther. 2009 Mar;328(3):900-11.