Name | arg-pro-lys-pro-gln-gln-phe-phe-pro-leu-met-nh2 |
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Synonyms |
H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Pro-Leu-Met-NH2
9-L-PROLINE-SUBSTANCE P substance P,Pro(9) RPKPQQFFPLM-NH2 [TYR9]-SUBSTANCE P [Pro9]SP [PRO9] SUBSTANCE P L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-L-Pro-L-Leu-L-Met-NH2 pro(9)-substance [Pro9]-Substance P |
Description | [Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM[1]. |
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Related Catalog | |
Target |
NK1:0.93 nM (EC50) |
In Vitro | [3H][Pro9]-Substance P can be used as a radio ligand for NK- 1 binding sites[1]. [Pro9]-Substance P stimulates inositol phosphate formation with an efficacy only slightly lower than that of SP (EC50 values of 0.93 ± 0.07 and 0.45 ± 0.06 nM, respectively) on primary cultures of newborn mouse cortical glial cells[1]. |
Density | 1.43g/cm3 |
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Molecular Formula | C66H102N18O13S |
Molecular Weight | 1387.69000 |
Exact Mass | 1386.76000 |
PSA | 533.14000 |
LogP | 4.61590 |
Index of Refraction | 1.669 |
WGK Germany | 3 |
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