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104486-69-3

104486-69-3 structure
104486-69-3 structure
  • Name: [Pro9]-Substance P
  • Chemical Name: arg-pro-lys-pro-gln-gln-phe-phe-pro-leu-met-nh2
  • CAS Number: 104486-69-3
  • Molecular Formula: C66H102N18O13S
  • Molecular Weight: 1387.69000
  • Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
  • Create Date: 2018-07-14 21:00:27
  • Modify Date: 2024-01-06 19:11:52
  • [Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM[1].

Name arg-pro-lys-pro-gln-gln-phe-phe-pro-leu-met-nh2
Synonyms H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Pro-Leu-Met-NH2
9-L-PROLINE-SUBSTANCE P
substance P,Pro(9)
RPKPQQFFPLM-NH2
[TYR9]-SUBSTANCE P
[Pro9]SP
[PRO9] SUBSTANCE P
L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-L-Pro-L-Leu-L-Met-NH2
pro(9)-substance
[Pro9]-Substance P
Description [Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM[1].
Related Catalog
Target

NK1:0.93 nM (EC50)

In Vitro [3H][Pro9]-Substance P can be used as a radio ligand for NK- 1 binding sites[1]. [Pro9]-Substance P stimulates inositol phosphate formation with an efficacy only slightly lower than that of SP (EC50 values of 0.93 ± 0.07 and 0.45 ± 0.06 nM, respectively) on primary cultures of newborn mouse cortical glial cells[1].
Density 1.43g/cm3
Molecular Formula C66H102N18O13S
Molecular Weight 1387.69000
Exact Mass 1386.76000
PSA 533.14000
LogP 4.61590
Index of Refraction 1.669
WGK Germany 3