Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CAY10580
Price:
Purity: 97.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: CAY10580
Price: $Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

64054-40-6

64054-40-6 structure

64054-40-6 structure

Name: CAY10580
Chemical Name: 7-[2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl]heptanoic acid
CAS Number: 64054-40-6
Molecular Formula: C₁₉H₃₅NO₄
Molecular Weight: 341.49
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2017-08-18 13:48:44
Modify Date: 2024-01-10 19:19:39
CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM)[1].

Name	7-[2-(3-hydroxyoctyl)-5-oxopyrrolidin-1-yl]heptanoic acid
Synonyms	7-[2-(3-Hydroxyoctyl)-5-oxo-1-pyrrolidinyl]heptanoic acid 1-Pyrrolidineheptanoic acid, 2-(3-hydroxyoctyl)-5-oxo-

Description	CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM)[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Metabolic Disease
Target	EP4:35 nM (Ki) EP4 Receptor:35 nM (Ki) EP2 Receptor:3000 nM (Ki) EP3 receptor:2000 nM (Ki)
In Vitro	CAY10580 (10-10000 nM; 40 min) significantly increases apical membrane abundance of AQP2 in MDCK cells at 100 to 10000 nM[2].
In Vivo	CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion[3]. Animal Model: Six-week old male EP4+/+ mice (Treating high fat diet-challenged mice)[3] Dosage: 200 μg/kg body weight Administration: Intraperitoneal injection; daily for remaining three weeks Result: High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.
References	[1]. Billot X, et al. Discovery of a potent and selective agonist of the prostaglandin EP4 receptor. Bioorg Med Chem Lett. 2003;13(6):1129-1132. [2]. Olesen ET, et al. Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus. Proc Natl Acad Sci U S A. 2011;108(31):12949-12954. [3]. Ying F, et al. EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(9):1029-1040.

Density	1.0±0.1 g/cm3
Boiling Point	534.4±25.0 °C at 760 mmHg
Molecular Formula	C₁₉H₃₅NO₄
Molecular Weight	341.49
Flash Point	277.0±23.2 °C
Exact Mass	341.256622
PSA	77.84000
LogP	2.88
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.494