112226-61-6

112226-61-6 structure

Name: HALOFENOZIDE
Chemical Name: halofenozide
CAS Number: 112226-61-6
Molecular Formula: C₁₈H₁₉ClN₂O₂
Molecular Weight: 330.81
Catalog: analytical chemistry Standard Pesticides, veterinary drugs and fertilizers
Create Date: 2018-07-30 20:31:18
Modify Date: 2024-01-04 17:38:37
Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone[1].

Name	halofenozide
Synonyms	RH 0345 N-tert-butyl-N’-(4-chlorobenzoyl)benzohydrazide N-tert-Butyl-N'-(4-chlorobenzoyl)benzohydrazide N'-benzoyl-N'-tert-butyl-4-chlorobenzohydrazide 4-chlorobenzoic acid 2-benzoyl-2-(1,1-dimethylethyl)hydrazide Mach 2 Halofenozide N’-benzoyl-N’-tert-butyl-4-chlorobenzohydrazide

Description	Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Halofenozide (RH-0345) reduces both growth and development of oocytes in vitro[1]. Cell Viability Assay[2] Cell Line: Cultured ovaries were dissected from female adult beetles of mealworm, Tenebrio molitor (T. molitor) Concentration: 1 μM and 10 μM Incubation Time: 4 days Result: Did not cause a significant effect on ecdysteroid amounts in the culture medium using ovaries from 0- and 2-day-old females at 10 μM. Caused a small significant increase of the amounts of ovarian ecdysteroids in the culture medium at 1 μM in the culture medium and with 2-day-old ovaries.
In Vivo	After topical application of Halofenozide (RH-0345; 5 and 10 μg) on adult females, the highest dose (10 μg) reduces significantly the reproductive parameters scored: namely the oviposition period, the fecundity and the egg viability[1]. Halofenozide at the two doses tested (5 and 10 μg) causes smaller eggs with a decrease in length, width and volume[1]. Animal Model: Newly emerged (0-day-old) adult females of T. molitor [1] Dosage: 5 and 10 μg Administration: Topically applied Result: Caused smaller eggs with a decrease in length, width and volume at the two doses tested (5 and 10 μg) .
References	[1]. Faïza Taïbi, et al. Effect of ecdysone agonist RH-0345 on reproduction of mealworm, Tenebrio molitor. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jul;135C(3):257-67.

Density	1.205g/cm3
Melting Point	198.0-199.0°
Molecular Formula	C₁₈H₁₉ClN₂O₂
Molecular Weight	330.81
Exact Mass	330.11400
PSA	49.41000
LogP	4.31660
Index of Refraction	1.584

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H317-H411
Precautionary Statements	P273-P280
Hazard Codes	Xi,N
Risk Phrases	43-51/53
Safety Phrases	24-37-61
RIDADR	UN 3077
RTECS	DG4976795
Packaging Group	III
Hazard Class	9

3140-73-6

23875-76-5

112226-61-6

Literature: EP982292 A2, ;

Precursor 2
3140-73-6 23875-76-5
DownStream 0