Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TS-011
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Purity: 98.0%
Stocking Period: 10 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: TS-011
Price: ￥888.0/50mg ￥2638.0/250mg
Purity: 98.0%
Stocking Period: 2 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMimidamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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339071-18-0

339071-18-0 structure

339071-18-0 structure

Name: TS-011
Chemical Name: N'-(3-chloro-4-morpholin-4-ylphenyl)-N-hydroxymethanimidamide
CAS Number: 339071-18-0
Molecular Formula: C₁₁H₁₄ClN₃O₂
Molecular Weight: 255.70100
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-12-13 16:12:45
Modify Date: 2024-01-11 07:47:14
TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.

Name	N'-(3-chloro-4-morpholin-4-ylphenyl)-N-hydroxymethanimidamide
Synonyms	TS-011 Methanimidamide,N-[3-chloro-4-(4-morpholinyl)phenyl]-N'-hydroxy

Description	TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease
In Vivo	TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05)[1]. In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%[2].
Animal Admin	The studies are performed using 58 male C57BL/6J mice (8 weeks old) weighing 20 to 26 g. TS-011 (0.3 mg/kg) or a vehicle is infused intravenously for 1 h every 6 h in a mouse model of stroke, induced by transient occlusion of the middle cerebral artery occlusion following photothrombosis. The cerebral blood flow velocity and the vascular perfusion area of the peri-infarct microvessels are measured using in vivo two-photon imaging[1].
References	[1]. Marumo T, et al. The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. Br J Pharmacol. 2010 Nov;161(6):1391-402. [2]. Hacein-Bey L, et al. Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2006 Jun-Jul;27(6):1350-4.

Boiling Point	477.8±55.0°C
Molecular Formula	C₁₁H₁₄ClN₃O₂
Molecular Weight	255.70100
Exact Mass	255.07700
PSA	57.09000
LogP	2.27110
Storage condition	2-8°C

Hazard Codes	Xi