556803-08-8

556803-08-8 structure

Name: TCN 213
Chemical Name: 2-{[5-(Benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(cyclohexyl methyl)acetamide
CAS Number: 556803-08-8
Molecular Formula: C₁₈H₂₄N₄OS₂
Molecular Weight: 376.53900
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2016-04-14 12:16:26
Modify Date: 2024-01-17 09:44:03
TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones[1][2].

Name	2-{[5-(Benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(cyclohexyl methyl)acetamide

Description	TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	GluN1/GluN2A NMDAR:0.55-40 μM (IC50)
In Vitro	TCN 213 (30 µM) antagonizes NMDA-evoked currents in neurones transfected with GluN2A subunits[1].
References	[1]. McKay, S et al. “Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.” British journal of pharmacology vol. 166,3 (2012): 924-37. [2]. Edman S, et al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep;63(3):441-9.

Hazard Codes	Xi
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%