TCN 213

Modify Date: 2024-01-17 09:44:03

TCN 213 Structure
TCN 213 structure
Common Name TCN 213
CAS Number 556803-08-8 Molecular Weight 376.53900
Density N/A Boiling Point N/A
Molecular Formula C18H24N4OS2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TCN 213


TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones[1][2].

 Names

Name 2-{[5-(Benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(cyclohexyl methyl)acetamide

 TCN 213 Biological Activity

Description TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones[1][2].
Related Catalog
Target

GluN1/GluN2A NMDAR:0.55-40 μM (IC50)

In Vitro TCN 213 (30 µM) antagonizes NMDA-evoked currents in neurones transfected with GluN2A subunits[1].
References

[1]. McKay, S et al. “Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.” British journal of pharmacology vol. 166,3 (2012): 924-37.

[2]. Edman S, et al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep;63(3):441-9.

 Chemical & Physical Properties

Molecular Formula C18H24N4OS2
Molecular Weight 376.53900
Exact Mass 376.13900
PSA 127.17000
LogP 4.20100

 Safety Information

Hazard Codes Xi
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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