176960-47-7

176960-47-7 structure

Name: BMS-193884
Chemical Name: N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide
CAS Number: 176960-47-7
Molecular Formula: C₂₀H₁₇N₃O₄S
Molecular Weight: 395.43200
Create Date: 2018-06-13 17:35:21
Modify Date: 2024-02-28 17:24:59
BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1].

Name	N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide

Description	BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Target	ETA:1.4 nM (Ki) ETB:18700 nM (Ki)
References	[1]. Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003;46(1):125-137.

176961-14-1

~53%

176960-47-7

Literature: Journal of Medicinal Chemistry, , vol. 43, # 16 p. 3111 - 3117

586-75-4

176960-47-7

Literature: Journal of Medicinal Chemistry, , vol. 43, # 16 p. 3111 - 3117

698-67-9

176960-47-7

Literature: Journal of Medicinal Chemistry, , vol. 43, # 16 p. 3111 - 3117

176961-50-5

176960-47-7

Literature: Journal of Medicinal Chemistry, , vol. 43, # 16 p. 3111 - 3117