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  • DC Chemicals Limited
  • China
  • Product Name: S6K-18
  • Price: $450.0/50mg $800.0/100mg $1500.0/250mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1265789-88-5

1265789-88-5 structure
1265789-88-5 structure
  • Name: S6K-18
  • Chemical Name: 2-(3-(1H-indazol-5-yl)ureido)-5-tert-butylthiophene-3-carboxylic acid
  • CAS Number: 1265789-88-5
  • Molecular Formula: C17H18N4O3S
  • Molecular Weight: 358.41
  • Catalog: Signaling Pathways MAPK/ERK Pathway Ribosomal S6 Kinase (RSK)
  • Create Date: 2016-02-24 05:46:06
  • Modify Date: 2024-01-12 08:48:02
  • S6K-18 is a potent and selective p70S6K1 inhibitor with an IC50 of 52 nM[1].

Name 2-(3-(1H-indazol-5-yl)ureido)-5-tert-butylthiophene-3-carboxylic acid
Synonyms 2-[(1H-Indazol-5-ylcarbamoyl)amino]-5-(2-methyl-2-propanyl)-3-thiophenecarboxylic acid
3-Thiophenecarboxylic acid, 5-(1,1-dimethylethyl)-2-[[(1H-indazol-5-ylamino)carbonyl]amino]-
S6K-18
Description S6K-18 is a potent and selective p70S6K1 inhibitor with an IC50 of 52 nM[1].
Related Catalog
Target

S6K1:52 nM (IC50)

References

[1]. Ye P, et al. Potent and selective thiophene urea-templated inhibitors of S6K. Bioorg Med Chem Lett. 2011 Jan 15;21(2):849-52.

Density 1.5±0.1 g/cm3
Boiling Point 494.9±45.0 °C at 760 mmHg
Molecular Formula C17H18N4O3S
Molecular Weight 358.41
Flash Point 253.1±28.7 °C
Exact Mass 358.109955
PSA 135.35000
LogP 5.22
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.746