Top Suppliers:I want be here


77739-21-0

77739-21-0 structure
77739-21-0 structure
  • Name: b-Neo-Endorphin
  • Chemical Name: β-Neoendorphin
  • CAS Number: 77739-21-0
  • Molecular Formula: C54H77N13O12
  • Molecular Weight: 1100.27000
  • Catalog: Signaling Pathways MAPK/ERK Pathway ERK
  • Create Date: 2017-08-30 02:10:37
  • Modify Date: 2024-01-08 23:02:35
  • β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9[1][2].

Name β-Neoendorphin
Synonyms L-Proline, L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-L-tyrosyl-
L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-L-tyrosyl-L-proline
β-Neoendorphin
β-neo-endorphin
b-Neo-Endorphin
Description β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9[1][2].
Related Catalog
Target

ERK1

ERK2

MMP-2

MMP-9

In Vitro β-Neo-Endorphin (0-20 μM, 20 h) stimulates wound healing in human keratinocytes[2]. β-Neo-Endorphin (promotes wound healing through activation of the Erk1/2 signaling pathway in human keratinocytes[2]. β-Neo-Endorphin (0-20 μM, 12 h) stimulates keratinocyte migration through activation of metalloproteinase (MMP)-2 and -9[2]. β-Neo-Endorphin (12 h) stimulates migration in the fibroblast[2]. Cell Viability Assay[2] Cell Line: Human keratinocytes (HaCaT) Concentration: 0, 5, 10 and 20 μM Incubation Time: 20 h Result: Significantly increased the wound closure. Had no observable effect on cell viability. Western Blot Analysis[2] Cell Line: Human keratinocytes (HaCaT) Concentration: 0, 5, 10 and 20 μM Incubation Time: 12 h Result: Activated Erk1/2, phosphorylated P90RSK and Elk-1, showed significant upregulation of MMP-2 and -9 expression.
Density 1.4±0.1 g/cm3
Molecular Formula C54H77N13O12
Molecular Weight 1100.27000
Exact Mass 1099.58000
PSA 418.21000
LogP 1.59
Index of Refraction 1.653