Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Reticuline
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Reticuline
Price: ￥2700.0/5mg
Purity: 97.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Reticuline
Price: ￥4000.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Reticuline
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

485-19-8

485-19-8 structure

485-19-8 structure

Name: Reticuline
Chemical Name: reticuline
CAS Number: 485-19-8
Molecular Formula: C₁₉H₂₃NO₄
Molecular Weight: 329.390
Catalog: Natural product Alkaloid
Create Date: 2018-08-21 22:03:40
Modify Date: 2024-01-06 16:33:24
Reticuline, isolated from Litsea cubeba, shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1].

Name	reticuline
Synonyms	1-(3-Hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol Reticuline 1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinol 2-Methyl-7-hydroxy-6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline 1-(3-Hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinol Coclanoline (±)-Reticuline 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-

Description	Reticuline, isolated from Litsea cubeba, shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> JAK/STAT Signaling >> STAT Research Areas >> Inflammation/Immunology
Target	JAK2 STAT3 NF-κB
References	[1]. Yang X, et al. Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways. Planta Med. 2018 Jan;84(1):20-25.

Density	1.2±0.1 g/cm3
Boiling Point	504.9±50.0 °C at 760 mmHg
Melting Point	125-126ºC
Molecular Formula	C₁₉H₂₃NO₄
Molecular Weight	329.390
Flash Point	259.2±30.1 °C
Exact Mass	329.162720
PSA	62.16000
LogP	2.09
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.604
Storage condition	-20?C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX5993000

CHEMICAL NAME :: 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-((3-hydroxy-4-methoxyphenyl)meth yl)-6-methoxy-2-methy l-,(S)-

CAS REGISTRY NUMBER :: 485-19-8

BEILSTEIN REFERENCE NO. :: 4299976

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H23-N-O4

MOLECULAR WEIGHT :: 329.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JNPRDF Journal of Natural Products. (Spahr & Glenn Co., 225 E. Spring St., Columbus, OH 43215) V.42- 1979- Volume(issue)/page/year: 42,399,1979

Hazard Codes	Xi

Precursor 7
621-59-0 2426-87-1 22231-61-4 1860-60-2
63909-38-6 55667-12-4 121-33-5
DownStream 10
3621-36-1 3019-51-0 4090-18-0 517-56-6
25650-75-3 483-45-4 605-34-5 56435-41-7
32728-75-9 524-46-9