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138-39-6

138-39-6 structure
138-39-6 structure
  • Name: Mafenide
  • Chemical Name: 4-Aminomethylbenzenesulfonamide
  • CAS Number: 138-39-6
  • Molecular Formula: C7H10N2O2S
  • Molecular Weight: 186.232
  • Catalog: API Synthetic anti-infective drugs Sulfonamides and synergists
  • Create Date: 2018-04-24 08:00:00
  • Modify Date: 2024-01-05 12:30:43
  • Mafenide is a sulfonamide-type medication.Target: AntibacterialMafenide is a sulfonamide-type medication. Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns. It is used to treat severe burns. It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns [1-3].
Name 4-Aminomethylbenzenesulfonamide
Synonyms 4-(Aminomethyl)benzenesulfonamide
EINECS 205-326-9
Benzenesulfonamide, 4-(aminomethyl)-
Description Mafenide is a sulfonamide-type medication.Target: AntibacterialMafenide is a sulfonamide-type medication. Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns. It is used to treat severe burns. It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns [1-3].
Related Catalog
References

[1]. Siuda, J.F. and C.D. Cihonski, New compounds: carbamate derivatives of mafenide (homosulfanilamide). J Pharm Sci, 1972. 61(11): p. 1856-7.

[2]. Haynes, B.W., Jr., Mafenide acetate in burn treatment. N Engl J Med, 1971. 284(23): p. 1324.

[3]. Haik, J., et al., Burn care standards in Israel: lack of consensus. Burns, 2005. 31(7): p. 845-9.
Density 1.3±0.1 g/cm3
Boiling Point 382.0±44.0 °C at 760 mmHg
Melting Point 177-178℃ (decomposition)
Molecular Formula C7H10N2O2S
Molecular Weight 186.232
Flash Point 184.8±28.4 °C
Exact Mass 186.046295
PSA 94.56000
LogP -0.80
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.602
Storage condition 2-8℃
Material Safety Data Sheet
Section1. Identification of the substance
Product Name: 4-Aminomethylbenzenesulfonamide
Synonyms:
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
Section3. Composition/information on ingredients.
Ingredient name:4-Aminomethylbenzenesulfonamide
CAS number:138-39-6
Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C7H10N2O2S
Molecular weight:186.2
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A
HS Code 2935009090
3119-02-6 structure

3119-02-6

~86%

138-39-6 structure

138-39-6

Literature: Lateef, Shaik; Mohan, Srinivasulu Reddy Krishna; Rameshraju, Rudraraju; Reddy, Srinivasulu; Reddy, Javarama Helvetica Chimica Acta, 2006 , vol. 89, # 6 p. 1254 - 1257
2015-14-7 structure

2015-14-7

~%

138-39-6 structure

138-39-6

Literature: Journal of the American Chemical Society, , vol. 66, p. 1459
28073-51-0 structure

28073-51-0

~%

138-39-6 structure

138-39-6

Literature: Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), , vol. 21, p. 681,683 Chem.Abstr., , p. 5540
14289-29-3 structure

14289-29-3

~%

138-39-6 structure

138-39-6

Literature: Journal of the American Chemical Society, , vol. 62, p. 2099,2101
588-46-5 structure

588-46-5

~%

138-39-6 structure

138-39-6

Literature: Journal of the American Chemical Society, , vol. 66, p. 1459
2522-79-4 structure

2522-79-4

~%

138-39-6 structure

138-39-6

Literature: DE726386 , ; DRP/DRBP Org.Chem.
HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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