87981-04-2

87981-04-2 structure

Name: Maleimide-C10-NHS ester
Chemical Name: 11-Maleimidoundecanoic Acid N-Succinimidyl Ester
CAS Number: 87981-04-2
Molecular Formula: C₁₉H₂₆N₂O₆
Molecular Weight: 378.419
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-04-07 08:00:00
Modify Date: 2024-01-09 21:34:48
Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	11-Maleimidoundecanoic Acid N-Succinimidyl Ester
Synonyms	(2,5-dioxopyrrolidin-1-yl) 11-(2,5-dioxopyrrol-1-yl)undecanoate 1-{11-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-11-oxoundecyl}-1H-pyrrole-2,5-dione

Description	Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.