100324-80-9

100324-80-9 structure

Name: UNII:R99EE080JS
Chemical Name: (S)-Lisofylline
CAS Number: 100324-80-9
Molecular Formula: C₁₃H₂₀N₄O₃
Molecular Weight: 280.323
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-05-27 02:57:59
Modify Date: 2024-01-11 17:02:52
(S)-Lisofylline ((S)-Lisophylline)) is a kind of lisofline (LSF) enantiomer with optical activity. (S)-Lisofylline can interconversion with pentoxifylline[1][2].

Name	(S)-Lisofylline
Synonyms	(S)-Lisofylline UNII:R99EE080JS Amendol 1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl- 1-[(5S)-5-Hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione Di-O-methyl-osajetin 1H-Purine-2,6-dione, 3,7-dihydro-1-[(5S)-5-hydroxyhexyl]-3,7-dimethyl- 1-(5-Hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione

Description	(S)-Lisofylline ((S)-Lisophylline)) is a kind of lisofline (LSF) enantiomer with optical activity. (S)-Lisofylline can interconversion with pentoxifylline[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	(S)-Lisofylline 在人溶血红细胞中能与己酮可可碱相互转化[2]。
In Vivo	(S)-Lisofylline (50 mg/kg；静脉注射；单剂量) 在小鼠肝脏、肾脏和肺部中显示出较高的含量，但在血清中含量较低[2]。
References	[1]. Borowiecki P, et al. Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/TEMPO)-alcohol dehydrogenase system[J]. Catalysis Science & Technology, 2022, 12(13): 4312-4324. [2]. Wyska E, et al. Interconversion and tissue distribution of pentoxifylline and lisofylline in mice. Chirality. 2006 Aug;18(8):644-51.