Shanghai Nianxing Industrial Co., Ltd
China
Product Name: gamma-Fagarine
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BioBioPha
China
Product Name: gamma-Fagarine
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: gamma-Fagarine
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DC Chemicals Limited
China
Product Name: γ-Fagarine
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: GAMMA-FAGARINE
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524-15-2

524-15-2 structure

524-15-2 structure

Name: gamma-Fagarine
Chemical Name: 4,8-Dimethoxyfuro[2,3-b]quinoline
CAS Number: 524-15-2
Molecular Formula: C₁₃H₁₁NO₃
Molecular Weight: 229.231
Catalog: Natural product Alkaloid
Create Date: 2017-06-21 03:17:47
Modify Date: 2024-01-02 19:21:47
γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC50 of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer[1][2].

Name	4,8-Dimethoxyfuro[2,3-b]quinoline
Synonyms	8-Methoxydictamine 8-Methoxydictamnine 4,8-Dimethoxyfuro[2,3-b]quinoline Fagarine Furo[2,3-b]quinoline, 4,8-dimethoxy- g-fagarine γ-Fagarine

Description	γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC50 of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
Target	IC50: 20.4 μg/mL (HCV)[1]
References	[1]. Tutik Sri Wahyuni, et al. Inhibition of Hepatitis C Virus Replication by Chalepin and Pseudane IX Isolated From Ruta Angustifolia Leaves. Fitoterapia. 2014 Dec;99:276-83. [2]. O Schimmer, et al. The SCE-inducing Potency of the Furoquinoline Alkaloid, Gamma-Fagarine, and a Gamma-Fagarine-Containing Tincture From Rutae Herba, in Cultured Human Lymphocytes. Mutagenesis. 1989 Nov;4(6):467-70.

Density	1.3±0.1 g/cm3
Boiling Point	381.0±37.0 °C at 760 mmHg
Melting Point	142°
Molecular Formula	C₁₃H₁₁NO₃
Molecular Weight	229.231
Flash Point	184.2±26.5 °C
Exact Mass	229.073898
PSA	44.49000
LogP	2.70
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.643

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV2708200

CHEMICAL NAME :: Furo(2,3-b)quinoline, 4,8-dimethoxy-

CAS REGISTRY NUMBER :: 524-15-2

BEILSTEIN REFERENCE NO. :: 0212820

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H11-N-O3

MOLECULAR WEIGHT :: 229.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 ug/plate

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,349,1988

Hazard Codes	Xi
HS Code	2934999090

Precursor 9
865878-14-4 186581-53-3 2255-50-7 865878-22-4
865878-23-5 55934-30-0 484-29-7 111163-82-7
827303-67-3
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%