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  • BioBioPha
  • China
  • Product Name: Dictamnine
  • Price: ¥Inquiry/5mg
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng


484-29-7

484-29-7 structure
484-29-7 structure
  • Name: Dictamnine
  • Chemical Name: 4-methoxyfuro[2,3-b]quinoline
  • CAS Number: 484-29-7
  • Molecular Formula: C12H9NO2
  • Molecular Weight: 199.205
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-09-28 10:11:22
  • Modify Date: 2024-01-03 13:12:46
  • Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.IC50 value:Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml [1]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis [2].

Name 4-methoxyfuro[2,3-b]quinoline
Synonyms 4-methoxyfuro[2,3-b]quinoline
Dictamine
Dictamnine
Furo[2,3-b]quinoline, 4-methoxy-
4-Methoxy-furo[2,3-b]quinoline
Description Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.IC50 value:Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml [1]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis [2].
Related Catalog
References

[1]. Guo N, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25(9):631-41.

[2]. An FF, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14(10):5895-900.

Density 1.3±0.1 g/cm3
Boiling Point 343.2±22.0 °C at 760 mmHg
Melting Point 133.5ºC
Molecular Formula C12H9NO2
Molecular Weight 199.205
Flash Point 161.4±22.3 °C
Exact Mass 199.063324
PSA 35.26000
LogP 2.94
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.672
Storage condition -20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LV2709700
CHEMICAL NAME :
Furo(2,3-b)quinoline, 4-methoxy-
CAS REGISTRY NUMBER :
484-29-7
BEILSTEIN REFERENCE NO. :
0176932
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H9-N-O2
MOLECULAR WEIGHT :
199.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
1 ug/plate
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,349,1988
Hazard Codes N