81039-85-2

81039-85-2 structure

Name: [DPro4,DTrp7,9] Substance P: 4-11
Chemical Name: d-pro-gln-gln-d-trp-phe-d-trp-leu-met-nh2
CAS Number: 81039-85-2
Molecular Formula: C₅₇H₇₅N₁₃O₁₀S
Molecular Weight: 1134.35000
Catalog: Research Areas Neurological Disease
Create Date: 2018-12-25 10:52:30
Modify Date: 2024-02-01 12:04:36
[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1].

Name	d-pro-gln-gln-d-trp-phe-d-trp-leu-met-nh2
Synonyms	H-D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2 [DPro4,DTrp7,9] Substance P: 4-11

Description	[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	[D-Pro4,D-Trp7,9] Substance P (4-11) inhibits the hypotensive effect of Substance P in anesthetized rats, the vasodilator effect in the rabbit perfused heart, relaxation induced by Substance P in dog carotid arteries contracted with noradrenaline, and stimulatory actions of Substance P in the guinea pig ileum and the guinea pig trachea[1]. [D-Pro4,D-Trp7,9] Substance P (4-11) (0.3 nM/K/min; i.p. for 7 days) significantly decreases plasma aldosterone (ALDO) concentration and causes atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells[2].
References	[1]. Mizrahi J, et al. Substance P antagonists active in vitro and in vivo. Eur J Pharmacol. 1982 Aug 13;82(1-2):101-5. [2]. Mazzocchi G, et al. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 1995 Jul;29(1):53-8.

87572-41-6

81039-85-2

Literature: Caranikas, S.; Mizrahi, J.; Escher, E.; Regoli, D. Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1313 - 1316