96426-21-0

96426-21-0 structure

Name: H-Gly-Arg-Gly-Asp-Ser-OH
Chemical Name: gly-arg-gly-asp-ser
CAS Number: 96426-21-0
Molecular Formula: C₁₇H₃₀N₈O₉
Molecular Weight: 490.46800
Catalog: Peptides
Create Date: 2018-12-05 15:24:25
Modify Date: 2024-01-10 01:59:20
Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin.

Name	gly-arg-gly-asp-ser
Synonyms	Gly-Arg-Gly-Asp-Ser-OH GRGDS 1/2ACOH 2H2O H-GLY-ARG-GLY-ASP-SER-OH GRGDS GRGDS,FIBRONECTIN ATTACHMENT PEPTIDE glycyl-arginyl-glycyl-aspartyl-serine MFCD00076459 L-Serine,glycyl-L-arginylglycyl-L-a-aspartyl

Description	Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Peptides
In Vitro	Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC50 of 5 μM[1]. GRGDS-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation[2].
References	[1]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997. [2]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

132304-02-0

96426-21-0

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 60, # 8.2. p. 1910 - 1918,1707 - 1713

132304-03-1

96426-21-0

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 60, # 8.2. p. 1910 - 1918,1707 - 1713

132304-04-2

96426-21-0

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 60, # 8.2. p. 1910 - 1918,1707 - 1713