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  • China
  • Product Name: Hydrangenol
  • Price: ￥2000.0/5mg
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng
Related CAS#:
480-47-7 82780-51-6
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480-47-7

480-47-7 structure
480-47-7 structure
  • Name: Hydrangenol
  • Chemical Name: hydrangenol
  • CAS Number: 480-47-7
  • Molecular Formula: C15H12O4
  • Molecular Weight: 256.253
  • Catalog: Natural product Coumarin
  • Create Date: 2018-09-29 12:17:32
  • Modify Date: 2024-01-02 17:15:30
  • Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1].
Name hydrangenol
Synonyms 3,4-Dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one
Hydrangenol
8-Hydroxy-3-(4-hydroxyphenyl)-3,4-dihydro-1H-isochromen-1-one
8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one
1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-
UNII:TL8PI7PHV1
8-Hydroxy-3-(4-hydroxy-phenyl)-isochroman-1-one
Description Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1].
Related Catalog
Target

MMP-1

MMP-3

COX-2

IL-6

In Vivo Hydrangenol (5, 10, 20, 或 40 mg/kg; 口服; 每日给药，共 7 周) 减轻 uvb 照射 HR-1 无毛小鼠的皱纹形成、背厚、脱水和胶原蛋白降解[1]。 Animal Model: UVB-irradiated HR-1 hairless mice[1] Dosage: 5, 10, 20, or 40 mg/kg Administration: Oral gavage; daily for 7 weeks Result: Increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation. Increased the expression of Pro-COL1A1. Decreased the expression matrix metalloproteinase (MMP)-1/-3, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6). Attenuated the phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK and p38, activator protein 1 (AP-1) subunit, and signal transduction and activation of transcription 1 (STAT1). Upregulated the expression of nuclear factor-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO-1), glutamate cysteine ligase modifier subunit (GCLM), and glutamate cysteine ligase catalysis subunit (GCLC).
References

[1]. Myung DB, et al. Hydrangenol Isolated from the Leaves of Hydrangea serrata Attenuates Wrinkle Formation and Repairs Skin Moisture in UVB-Irradiated Hairless Mice. Nutrients. 2019 Oct 2;11(10):2354.  

Density 1.4±0.1 g/cm3
Boiling Point 528.3±50.0 °C at 760 mmHg
Molecular Formula C15H12O4
Molecular Weight 256.253
Flash Point 206.4±23.6 °C
Exact Mass 256.073547
PSA 66.76000
LogP 2.54
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.662
Hazard Codes Xi

Chemsrc provides CAS#:480-47-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 480-47-7 | Chemsrc address: https://www.chemsrc.com/en/baike/554193.html

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