1052089-16-3

1052089-16-3 structure

Name: PSB 06126
Chemical Name: sodium 1-amino-4-(1-naphthylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
CAS Number: 1052089-16-3
Molecular Formula: C₂₄H₁₅N₂NaO₅S
Molecular Weight: 466.44100
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2016-05-02 16:29:38
Modify Date: 2024-08-14 18:00:30
PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the Ki values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC50 value of 7.76 μM and a Ki value of 4.39 μM[1][2].

Name	sodium 1-amino-4-(1-naphthylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate

Description	PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the Ki values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC50 value of 7.76 μM and a Ki value of 4.39 μM[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	Ki: 0.33 μM (rat NTPDase 1), 19.1 μM (rat NTPDase 2), 2.22 μM (rat NTPDase 3)，4.39 μM (human NTPDase 3)[1][2].
In Vitro	PSB 06126 (3 μM) blocks NTPDase3 overexpressed in mesenchymal stem cells (MSCs), leading to increased extracellular ATP levels and osteogenic differentiation and mineralisation of MSCs through activation of P2X7 and P2Y6 receptors[3].
References	[1]. Younis Baqi, et al. Ecto-nucleotidase inhibitors: recent developments in drug discovery. Mini Rev Med Chem. 2015;15(1):21-33. [2]. Amelie Fiene, et al. Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity. Analyst. 2015 Jan 7;140(1):140-8. [3]. J B Noronha-Matos, et al. Mesenchymal Stem Cells Ageing: Targeting the "Purinome" to Promote Osteogenic Differentiation and Bone Repair. J Cell Physiol. 2016 Sep;231(9):1852-61.