144481-98-1

144481-98-1 structure

Name: Landiolol Hydrochloride
Chemical Name: Landiolol hydrochloride
CAS Number: 144481-98-1
Molecular Formula: C₂₅H₄₀ClN₃O₈
Molecular Weight: 546.053
Catalog: API Circulatory system medication Beta-adrenergic receptor blocker
Create Date: 2018-04-29 08:00:00
Modify Date: 2024-01-02 18:03:04
Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min)， acts as an adrenoceptor antagonist[1].

Name	Landiolol hydrochloride
Synonyms	((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-(2-(morpholine-4-carboxamido)ethylamino)propoxy)phenyl)propanoate hydrochloride [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate hydrochloride (-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-3-[4-[(S)-2-hydroxy-3-(2-morpholinocarbonylamino)ethylamino]propoxy]phenylpropionic acid hydrochloride (-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(S)-2-hydroxy-3-(2-(morpholinocarbonylamino)ethylamino)propoxy]phenyl]propionate monohydrochloride Benzenepropanoic acid,4-(2-hydroxy-3-((2-((4-morpholinylcarbonyl)amino)ethyl)amino)propoxy)-,(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester,(S-(R,R))-,hydrochloride Landiololhydrochloride Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester, hydrochloride (1:1) Ono 1101 hydrochloride 2,2-dimethyl-1,3-dioxolan-4S-yl-methyl 3-[P-{3-{(2-(morpholinocarbonylamino)ethyl)amino}-2S-hydroxypropoxy}phenyl] propionate hydrochloride [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-{4-[(2S)-2-hydroxy-3-({2-[(4-morpholinylcarbonyl)amino]ethyl}amino)propoxy]phenyl}propanoate hydrochloride (1:1)

Description	Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min)， acts as an adrenoceptor antagonist[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	beta-adrenergic receptor[1]
References	[1]. Atarashi H, et al. Pharmacokinetics of landiolol hydrochloride, a new ultra-short-acting beta-blocker, in patients with cardiac arrhythmias. Clin Pharmacol Ther. 2000 Aug;68(2):143-50. [2]. Okajima M, et al. Landiolol, an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis. World J Crit Care Med. 2015 Aug 4;4(3):251-7.

Density	1.201g/cm3
Boiling Point	727.5ºC at 760mmHg
Melting Point	122-127ºC
Molecular Formula	C₂₅H₄₀ClN₃O₈
Molecular Weight	546.053
Flash Point	393.8ºC
Exact Mass	545.250366
PSA	127.82000
LogP	2.37760
Vapour Pressure	3.24E-22mmHg at 25°C

RTECS	DA8346700

154467-16-0

144256-11-1

106-89-8

~48%

144481-98-1

Literature: Procos S.p.A.; Garavaglia, Fabio; Roletto, Jacopo; Paissoni, Paolo Patent: EP2687521 A1, 2014 ; Location in patent: Paragraph 0053; 0054; 0055; 0056; 0057 ;

133242-30-5

~77%

144481-98-1

Literature: Procos S.p.A.; Garavaglia, Fabio; Roletto, Jacopo; Paissoni, Paolo Patent: EP2687521 A1, 2014 ; Location in patent: Paragraph 0051; 0052 ;

144256-11-1

144481-98-1

Literature: EP2687521 A1, ;

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