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  • DC Chemicals Limited
  • China
  • Product Name: Psychosine
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

2238-90-6

2238-90-6 structure
2238-90-6 structure
  • Name: Psychosine
  • Chemical Name: psychosine
  • CAS Number: 2238-90-6
  • Molecular Formula: C24H47NO7
  • Molecular Weight: 461.63200
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-04-24 08:00:00
  • Modify Date: 2024-01-02 16:30:06
  • Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease[1]. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC[1].

Name psychosine
Synonyms Galactosylsphingosine
D-galactosyl-ß1-1'-D-erythro-sphingosine
1-B-D-GALACTOSYLSPHINOGOSINE
Psychosine from bovine brain
PSYCHOSIN
PSYCHOSINE
D-GALACTOSYL-B1-1' SPHINGOSN
LYSO-CERAMIDEGALACTOSIDE
MFCD00057505
O-Galactosylsphingosine
LYSO-CEREBROSIDE
Description Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease[1]. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC[1].
Related Catalog
Target

PKC

In Vitro Psychosine, is a substrate of the GALC enzyme that shows promise to aid in the diagnosis and follow-up of at-risk infants identified through newborn screening (NBS)[1]. Psychosine induces pleiotropic effects, including dysfunctions in several cellular pathways[2]. Cell Viability Assay[2] Cell Line: Oligodendrocyte cells, M03.13 Concentration: 10, 20, and 40 μM Incubation Time: 24 hours Result: Caused cell death at least in part via apoptosis.
References

[1]. M L Escolar, et al. Psychosine, a marker of Krabbe phenotype and treatment effect. Mol Genet Metab. 2017 Jul;121(3):271-278.

[2]. Jacqueline A Hawkins-Salsbury,et al.Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture. J Lipid Res.2013 Dec;54(12):3303-11.

Density 1.14 g/cm3
Boiling Point 664.3ºC
Molecular Formula C24H47NO7
Molecular Weight 461.63200
Flash Point 355.6ºC
Exact Mass 461.33500
PSA 145.63000
LogP 2.44870
Vapour Pressure 1.77E-20mmHg at 25°C
Index of Refraction 1.535
Storage condition −20°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 36
RIDADR NONH for all modes of transport
Precursor  0

DownStream  3