Name | 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol |
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Synonyms |
tert-butyl N-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]carbamate
N-Boc-PEG4-alcohol |
Description | PROTAC Linker 12 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 12 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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Related Catalog | |
Target |
Alkyl/ether |
References |
Density | 1.078g/cm3 |
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Boiling Point | 414ºC at 760mmHg |
Molecular Formula | C13H27NO6 |
Molecular Weight | 293.35700 |
Flash Point | 204.2ºC |
Exact Mass | 293.18400 |
PSA | 86.25000 |
LogP | 0.94410 |
Vapour Pressure | 0mmHg at 25°C |
Index of Refraction | 1.459 |
Hazard Codes | Xn |
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HS Code | 2924199090 |
~87% 106984-09-2 |
Literature: Lebeau, Luc; Oudet, Pierre; Mioskowski, Charles Helvetica Chimica Acta, 1991 , vol. 74, # 8 p. 1697 - 1706 |
~52% 106984-09-2 |
Literature: Ling, Frank H.; Lu, Victor; Svec, Frantisek; Frechet, Jean M. J. Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 1993 - 2002 |
~84% 106984-09-2 |
Literature: Kueny-Stotz, Marie; Mamlouk-Chaouachi, Hind; Felder-Flesch, Delphine Tetrahedron Letters, 2011 , vol. 52, # 22 p. 2906 - 2909 |
~% 106984-09-2 |
Literature: Helvetica Chimica Acta, , vol. 74, # 8 p. 1697 - 1706 |
~% 106984-09-2 |
Literature: Helvetica Chimica Acta, , vol. 74, # 8 p. 1697 - 1706 |
~% 106984-09-2 |
Literature: Helvetica Chimica Acta, , vol. 74, # 8 p. 1697 - 1706 |
~% 106984-09-2 |
Literature: Inorganica Chimica Acta, , vol. 365, # 1 p. 38 - 48 |
Precursor 7 | |
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DownStream 2 | |
HS Code | 2924199090 |
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Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |